FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006061640> ?p ?o ?g. }

• W2006061640 endingPage "2079" @default.
• W2006061640 startingPage "2069" @default.
• W2006061640 abstract "To examine protein oxidation in systemic lupus erythematosus (SLE) and to correlate levels of protein oxidation products with disease activity.Serum was collected from SLE patients and healthy control subjects. Protein-bound carbonyls and the pro-oxidant enzyme myeloperoxidase (MPO) were quantified by enzyme-linked immunosorbent assay. Protein thiols were quantified using 5,5'-dithionitrobenzoic acid. Protein-bound amino acids and methionine, tyrosine, and phenylalanine oxidation products were quantified by acid hydrolysis and high-performance liquid chromatography. Disease activity was assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI). Levels of anti-double-stranded DNA (anti-dsDNA) antibodies were measured by radioimmunoassay.Compared with control subjects, SLE patients exhibited elevated levels of protein carbonyls (0.108 +/- 0.078 versus 0.064 +/- 0.028 nmoles/mg of protein; P = 0.046), decreased levels of protein thiols (3.9 +/- 1.1 versus 4.9 +/- 0.7 nmoles/mg of protein; P = 0.003), decreased levels of protein-bound methionine (P = 0.0007), and increased levels of protein-bound methionine sulfoxide (P = 0.0043) and 3-nitrotyrosine (P = 0.0477). SLE patients with high SLEDAI scores or elevated anti-dsDNA antibody levels exhibited increased oxidation compared with patients with low SLEDAI scores or low antibody levels. Serum MPO levels were decreased in SLE patients (P = 0.03), suggesting that this enzyme is not responsible for the enhanced protein oxidation.We found elevated levels of multiple markers of protein oxidation in sera from SLE patients compared with controls, and these levels correlated with disease activity. The findings suggest that protein oxidation may play a role in the pathogenesis of chronic organ damage in SLE." @default.
• W2006061640 created "2016-06-24" @default.
• W2006061640 creator A5069317976 @default.
• W2006061640 creator A5073258144 @default.
• W2006061640 creator A5078222317 @default.
• W2006061640 date "2005-01-01" @default.
• W2006061640 modified "2023-09-29" @default.
• W2006061640 title "Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus" @default.
• W2006061640 cites W1163687489 @default.
• W2006061640 cites W1566636169 @default.
• W2006061640 cites W1574128379 @default.
• W2006061640 cites W1602773114 @default.
• W2006061640 cites W1757241200 @default.
• W2006061640 cites W1759706356 @default.
• W2006061640 cites W1926950498 @default.
• W2006061640 cites W1971515850 @default.
• W2006061640 cites W1971531833 @default.
• W2006061640 cites W1984288246 @default.
• W2006061640 cites W1994051814 @default.
• W2006061640 cites W1994429566 @default.
• W2006061640 cites W2001035425 @default.
• W2006061640 cites W2009328811 @default.
• W2006061640 cites W2011683287 @default.
• W2006061640 cites W2013204959 @default.
• W2006061640 cites W2022970599 @default.
• W2006061640 cites W2029528806 @default.
• W2006061640 cites W2029890282 @default.
• W2006061640 cites W2031480377 @default.
• W2006061640 cites W2036806484 @default.
• W2006061640 cites W2039525899 @default.
• W2006061640 cites W2041945932 @default.
• W2006061640 cites W2044381004 @default.
• W2006061640 cites W2044410409 @default.
• W2006061640 cites W2048753387 @default.
• W2006061640 cites W2050730115 @default.
• W2006061640 cites W2050928917 @default.
• W2006061640 cites W2059499535 @default.
• W2006061640 cites W2059578393 @default.
• W2006061640 cites W2064999867 @default.
• W2006061640 cites W2066768847 @default.
• W2006061640 cites W2070527591 @default.
• W2006061640 cites W2072466025 @default.
• W2006061640 cites W2078697962 @default.
• W2006061640 cites W2080141721 @default.
• W2006061640 cites W2083525090 @default.
• W2006061640 cites W2093460800 @default.
• W2006061640 cites W2099776063 @default.
• W2006061640 cites W2107919301 @default.
• W2006061640 cites W2113059823 @default.
• W2006061640 cites W2117556617 @default.
• W2006061640 cites W2124295107 @default.
• W2006061640 cites W2125535836 @default.
• W2006061640 cites W2128330934 @default.
• W2006061640 cites W2132678730 @default.
• W2006061640 cites W2135110724 @default.
• W2006061640 cites W2139480666 @default.
• W2006061640 cites W2147544321 @default.
• W2006061640 cites W2149790826 @default.
• W2006061640 cites W2153483615 @default.
• W2006061640 cites W2153801933 @default.
• W2006061640 cites W2165779517 @default.
• W2006061640 cites W2468858310 @default.
• W2006061640 doi "https://doi.org/10.1002/art.21130" @default.
• W2006061640 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15986354" @default.
• W2006061640 hasPublicationYear "2005" @default.
• W2006061640 type Work @default.
• W2006061640 sameAs 2006061640 @default.
• W2006061640 citedByCount "118" @default.
• W2006061640 countsByYear W20060616402012 @default.
• W2006061640 countsByYear W20060616402013 @default.
• W2006061640 countsByYear W20060616402014 @default.
• W2006061640 countsByYear W20060616402015 @default.
• W2006061640 countsByYear W20060616402016 @default.
• W2006061640 countsByYear W20060616402017 @default.
• W2006061640 countsByYear W20060616402018 @default.
• W2006061640 countsByYear W20060616402019 @default.
• W2006061640 countsByYear W20060616402020 @default.
• W2006061640 countsByYear W20060616402021 @default.
• W2006061640 countsByYear W20060616402022 @default.
• W2006061640 crossrefType "journal-article" @default.
• W2006061640 hasAuthorship W2006061640A5069317976 @default.
• W2006061640 hasAuthorship W2006061640A5073258144 @default.
• W2006061640 hasAuthorship W2006061640A5078222317 @default.
• W2006061640 hasBestOaLocation W20060616401 @default.
• W2006061640 hasConcept C126322002 @default.
• W2006061640 hasConcept C134018914 @default.
• W2006061640 hasConcept C159654299 @default.
• W2006061640 hasConcept C181199279 @default.
• W2006061640 hasConcept C185592680 @default.
• W2006061640 hasConcept C203014093 @default.
• W2006061640 hasConcept C203565725 @default.
• W2006061640 hasConcept C2775915377 @default.
• W2006061640 hasConcept C2776165026 @default.
• W2006061640 hasConcept C2776914184 @default.
• W2006061640 hasConcept C2777431362 @default.
• W2006061640 hasConcept C2780912031 @default.
• W2006061640 hasConcept C515207424 @default.
• W2006061640 hasConcept C55493867 @default.

• next