FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006063385> ?p ?o ?g. }

• W2006063385 endingPage "2320" @default.
• W2006063385 startingPage "2312" @default.
• W2006063385 abstract "Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein which plays multiple roles in different types of cancer. Our previous study showed that SPARC overexpression inhibited the growth and angiogenesis of tumors, and reduced expression of vascular endothelial growth factor (VEGF). However, the relationship between SPARC expression and clinicopathological factors of gastric cancer (GC) is controversial, and the role of SPARC in GC remains unclear. We evaluated expression of SPARC in 65 human GC tissues using immunohistochemistry (IHC). The results indicated that SPARC expression was negatively correlated with clinicopathological factors of GC. In vitro assay showed that SPARC overexpression decreased proliferation and clonogenicity by suppressing CD44 expression. In addition, SPARC overexpression inhibited VEGF induced proliferation and arrested cell cycle of GC cells by reducing the activation of VEGFR2, ERK1/2 and AKT signaling pathways. SPARC suppressed the invasion and migration of GC by reducing MMP-7, MMP-9, N-cadherin, Sp1 and p-ERK1/2 expression. In the in vivo assay, cancer metastasis mouse models were established by tail vein injection. The results revealed that the lung metastases of SPARC-overexpressing GC cells in the mice were much fewer than those of control cells." @default.
• W2006063385 created "2016-06-24" @default.
• W2006063385 creator A5003309047 @default.
• W2006063385 creator A5006822602 @default.
• W2006063385 creator A5025412257 @default.
• W2006063385 creator A5031337173 @default.
• W2006063385 creator A5040036474 @default.
• W2006063385 creator A5041337778 @default.
• W2006063385 creator A5046597133 @default.
• W2006063385 creator A5053578321 @default.
• W2006063385 creator A5056524104 @default.
• W2006063385 creator A5076776059 @default.
• W2006063385 creator A5077934665 @default.
• W2006063385 creator A5078310500 @default.
• W2006063385 date "2014-03-27" @default.
• W2006063385 modified "2023-10-01" @default.
• W2006063385 title "SPARC expression is negatively correlated with clinicopathological factors of gastric cancer and inhibits malignancy of gastric cancer cells" @default.
• W2006063385 cites W1967518731 @default.
• W2006063385 cites W1971873096 @default.
• W2006063385 cites W1981989535 @default.
• W2006063385 cites W1982475740 @default.
• W2006063385 cites W1989859149 @default.
• W2006063385 cites W2000320547 @default.
• W2006063385 cites W2001311476 @default.
• W2006063385 cites W2018162829 @default.
• W2006063385 cites W2024520801 @default.
• W2006063385 cites W2025522465 @default.
• W2006063385 cites W2025854516 @default.
• W2006063385 cites W2027078891 @default.
• W2006063385 cites W2029697713 @default.
• W2006063385 cites W2047335027 @default.
• W2006063385 cites W2048052967 @default.
• W2006063385 cites W2058524493 @default.
• W2006063385 cites W2058843508 @default.
• W2006063385 cites W2060285807 @default.
• W2006063385 cites W2075098308 @default.
• W2006063385 cites W2076825931 @default.
• W2006063385 cites W2091022732 @default.
• W2006063385 cites W2101160783 @default.
• W2006063385 cites W2106787323 @default.
• W2006063385 cites W2116502464 @default.
• W2006063385 cites W2119491428 @default.
• W2006063385 doi "https://doi.org/10.3892/or.2014.3118" @default.
• W2006063385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24676680" @default.
• W2006063385 hasPublicationYear "2014" @default.
• W2006063385 type Work @default.
• W2006063385 sameAs 2006063385 @default.
• W2006063385 citedByCount "27" @default.
• W2006063385 countsByYear W20060633852015 @default.
• W2006063385 countsByYear W20060633852016 @default.
• W2006063385 countsByYear W20060633852017 @default.
• W2006063385 countsByYear W20060633852018 @default.
• W2006063385 countsByYear W20060633852019 @default.
• W2006063385 countsByYear W20060633852020 @default.
• W2006063385 countsByYear W20060633852021 @default.
• W2006063385 countsByYear W20060633852022 @default.
• W2006063385 countsByYear W20060633852023 @default.
• W2006063385 crossrefType "journal-article" @default.
• W2006063385 hasAuthorship W2006063385A5003309047 @default.
• W2006063385 hasAuthorship W2006063385A5006822602 @default.
• W2006063385 hasAuthorship W2006063385A5025412257 @default.
• W2006063385 hasAuthorship W2006063385A5031337173 @default.
• W2006063385 hasAuthorship W2006063385A5040036474 @default.
• W2006063385 hasAuthorship W2006063385A5041337778 @default.
• W2006063385 hasAuthorship W2006063385A5046597133 @default.
• W2006063385 hasAuthorship W2006063385A5053578321 @default.
• W2006063385 hasAuthorship W2006063385A5056524104 @default.
• W2006063385 hasAuthorship W2006063385A5076776059 @default.
• W2006063385 hasAuthorship W2006063385A5077934665 @default.
• W2006063385 hasAuthorship W2006063385A5078310500 @default.
• W2006063385 hasBestOaLocation W20060633851 @default.
• W2006063385 hasConcept C121608353 @default.
• W2006063385 hasConcept C142724271 @default.
• W2006063385 hasConcept C1491633281 @default.
• W2006063385 hasConcept C167734588 @default.
• W2006063385 hasConcept C203014093 @default.
• W2006063385 hasConcept C204232928 @default.
• W2006063385 hasConcept C2777025900 @default.
• W2006063385 hasConcept C2779013556 @default.
• W2006063385 hasConcept C2780394083 @default.
• W2006063385 hasConcept C2780932548 @default.
• W2006063385 hasConcept C2781018059 @default.
• W2006063385 hasConcept C29537977 @default.
• W2006063385 hasConcept C502942594 @default.
• W2006063385 hasConcept C54355233 @default.
• W2006063385 hasConcept C62112901 @default.
• W2006063385 hasConcept C67082663 @default.
• W2006063385 hasConcept C71924100 @default.
• W2006063385 hasConcept C86803240 @default.
• W2006063385 hasConcept C96232424 @default.
• W2006063385 hasConceptScore W2006063385C121608353 @default.
• W2006063385 hasConceptScore W2006063385C142724271 @default.
• W2006063385 hasConceptScore W2006063385C1491633281 @default.
• W2006063385 hasConceptScore W2006063385C167734588 @default.
• W2006063385 hasConceptScore W2006063385C203014093 @default.
• W2006063385 hasConceptScore W2006063385C204232928 @default.
• W2006063385 hasConceptScore W2006063385C2777025900 @default.
• W2006063385 hasConceptScore W2006063385C2779013556 @default.

• next