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• W2006064720 abstract "Abstract Activating transcription factor 3 (ATF3) is a basic leucine zipper transcription factor that plays a regulatory role in inflammation, cell division, and apoptosis. Mast cells (MCs) initiate many inflammatory responses and have a central role in allergy and allergic diseases. We report here that ATF3 has a central role in MC development and function. Bone marrow–derived MC populations from ATF3-deficient mice are unresponsive to interleukin-3 (IL-3)–induced maturation signals, and this correlates with increased apoptosis, diminished activation of the Akt kinase, and decreased phosphorylation of the proapoptotic protein Bad. Furthermore, ATF3-null mice lacked MCs in the peritoneum and dermis, showing that the in vitro results are recapitulated in vivo. ATF3-null MCs also showed functional defects; high-affinity immunoglobulin E receptor–mediated degranulation was significantly inhibited, whereas IL-4 and IL-6 expression was enhanced. This dual role of ATF3 provides insight into the complex interplay between MC development and its subsequent physiologic role." @default.
• W2006064720 created "2016-06-24" @default.
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• W2006064720 date "2010-06-10" @default.
• W2006064720 modified "2023-10-16" @default.
• W2006064720 title "A key role for ATF3 in regulating mast cell survival and mediator release" @default.
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• W2006064720 doi "https://doi.org/10.1182/blood-2009-03-213512" @default.
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