FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006074197> ?p ?o ?g. }

• W2006074197 endingPage "136" @default.
• W2006074197 startingPage "125" @default.
• W2006074197 abstract "The mechanisms by which aluminum interacts with the nervous system are only partly understood. In this study, we used cultured astrocytes and neurons to investigate the effects of long exposures to aluminum (1 mM). We found that aluminum accumulated both in neurons and astrocytes. After 8–12 days exposure, aluminum caused strong changes in the morphology of astrocytes including shrinkage of cell bodies and retraction of processes. Exposures over 15–18 days reduced astrocytes viability by 50%. Aluminum-induced degeneration of astrocytes involved the DNA fragmentation characteristic of apoptosis, and staining of aluminum-treated astrocytes with the DNA-binding fluorochrome Hoeschst 33258 revealed the typical apoptotic condensation and fragmentation of chromatin. Aluminum was also found to be neurotoxic, causing first (4–6 days) abnormal clustering and aggregation, and later (8–12 days) neuronal death. Interestingly, aluminum neurotoxicity occurred in neuroglial cultures containing approximately 10% astrocytes but not in near-pure neuronal cultures containing only 1% astrocytes. Staining of co-cultured cells with Hoeschst 33258 showed apoptotic condensation and fragmentation of chromatin in aluminum-treated astrocytes but not in co-cultured neurons. Our study demonstrates that aluminum can induce the apoptotic degeneration of astrocytes, and that this toxicity is critical in determining neuronal degeneration and death. Aluminum-mediated apoptosis of cultured astrocytes may be also a valuable model system to study the mechanisms underlying apoptosis in glial cells." @default.
• W2006074197 created "2016-06-24" @default.
• W2006074197 creator A5003062463 @default.
• W2006074197 creator A5006274229 @default.
• W2006074197 creator A5046081835 @default.
• W2006074197 creator A5063756912 @default.
• W2006074197 creator A5072077240 @default.
• W2006074197 creator A5083615353 @default.
• W2006074197 date "1999-07-01" @default.
• W2006074197 modified "2023-10-11" @default.
• W2006074197 title "Aluminum-induced degeneration of astrocytes occurs via apoptosis and results in neuronal death" @default.
• W2006074197 cites W1534491461 @default.
• W2006074197 cites W1557439744 @default.
• W2006074197 cites W1636078186 @default.
• W2006074197 cites W1678726420 @default.
• W2006074197 cites W173090205 @default.
• W2006074197 cites W1836838655 @default.
• W2006074197 cites W1949402654 @default.
• W2006074197 cites W1965366444 @default.
• W2006074197 cites W1970878503 @default.
• W2006074197 cites W1971213127 @default.
• W2006074197 cites W1974342751 @default.
• W2006074197 cites W1976265701 @default.
• W2006074197 cites W1977707442 @default.
• W2006074197 cites W1980248994 @default.
• W2006074197 cites W1982639834 @default.
• W2006074197 cites W1986318523 @default.
• W2006074197 cites W1987398476 @default.
• W2006074197 cites W1990719784 @default.
• W2006074197 cites W1990760619 @default.
• W2006074197 cites W1992574490 @default.
• W2006074197 cites W1994696744 @default.
• W2006074197 cites W2001320373 @default.
• W2006074197 cites W2010430324 @default.
• W2006074197 cites W2012584819 @default.
• W2006074197 cites W2015794252 @default.
• W2006074197 cites W2024902909 @default.
• W2006074197 cites W2029950762 @default.
• W2006074197 cites W2030442336 @default.
• W2006074197 cites W2033732703 @default.
• W2006074197 cites W2034098906 @default.
• W2006074197 cites W2036399425 @default.
• W2006074197 cites W2039490668 @default.
• W2006074197 cites W2045851297 @default.
• W2006074197 cites W2048946679 @default.
• W2006074197 cites W2054417790 @default.
• W2006074197 cites W2061245016 @default.
• W2006074197 cites W2062571325 @default.
• W2006074197 cites W2071695496 @default.
• W2006074197 cites W2072286244 @default.
• W2006074197 cites W2073885975 @default.
• W2006074197 cites W2082249282 @default.
• W2006074197 cites W2082975967 @default.
• W2006074197 cites W2083156858 @default.
• W2006074197 cites W2083394505 @default.
• W2006074197 cites W2084504852 @default.
• W2006074197 cites W2084609653 @default.
• W2006074197 cites W2084722225 @default.
• W2006074197 cites W2090970493 @default.
• W2006074197 cites W2095519131 @default.
• W2006074197 cites W2107100596 @default.
• W2006074197 cites W2124697229 @default.
• W2006074197 cites W2124952221 @default.
• W2006074197 cites W2134205510 @default.
• W2006074197 cites W2141133962 @default.
• W2006074197 cites W2141892357 @default.
• W2006074197 cites W2147629297 @default.
• W2006074197 cites W2156608999 @default.
• W2006074197 cites W2169518110 @default.
• W2006074197 cites W2352584082 @default.
• W2006074197 cites W2397460217 @default.
• W2006074197 cites W2436948428 @default.
• W2006074197 cites W4253645623 @default.
• W2006074197 cites W81848546 @default.
• W2006074197 cites W2015288922 @default.
• W2006074197 doi "https://doi.org/10.1016/s0006-8993(99)01536-x" @default.
• W2006074197 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10415367" @default.
• W2006074197 hasPublicationYear "1999" @default.
• W2006074197 type Work @default.
• W2006074197 sameAs 2006074197 @default.
• W2006074197 citedByCount "123" @default.
• W2006074197 countsByYear W20060741972012 @default.
• W2006074197 countsByYear W20060741972013 @default.
• W2006074197 countsByYear W20060741972014 @default.
• W2006074197 countsByYear W20060741972015 @default.
• W2006074197 countsByYear W20060741972016 @default.
• W2006074197 countsByYear W20060741972017 @default.
• W2006074197 countsByYear W20060741972018 @default.
• W2006074197 countsByYear W20060741972019 @default.
• W2006074197 countsByYear W20060741972020 @default.
• W2006074197 countsByYear W20060741972021 @default.
• W2006074197 countsByYear W20060741972022 @default.
• W2006074197 countsByYear W20060741972023 @default.
• W2006074197 crossrefType "journal-article" @default.
• W2006074197 hasAuthorship W2006074197A5003062463 @default.
• W2006074197 hasAuthorship W2006074197A5006274229 @default.
• W2006074197 hasAuthorship W2006074197A5046081835 @default.
• W2006074197 hasAuthorship W2006074197A5063756912 @default.

• next