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- W2006075304 abstract "In a directed effort to elucidate the molecular factors responsible for selectin-mediated cell adhesion events as a basis for the generation of potent and specific inhibitors of these processes, we have synthesized a variety of sulfated analogs of the trisaccharide recognition epitopes Lewis a [Lea: Galβ1→3(Fucα1→4)GlcNAc] and Lewis x [Lex: Galβ1→4(Fucα1→3)GlcNAc]. Our divergent synthetic route allows for the synthesis of gram quantities of these sulfated trisaccharides from common intermediates in 10–20% overall yields and in no more than 15 linear steps. In addition, we have anchored the reducing end of the Lea and Lex trisaccharide precursors with a β-allyl aglycone, providing a single anomer of each final product and allowing for further modification into multivalent derivatives." @default.
- W2006075304 created "2016-06-24" @default.
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- W2006075304 date "1997-12-01" @default.
- W2006075304 modified "2023-10-17" @default.
- W2006075304 title "Synthesis of sulfated trisaccharide ligands for the selectins" @default.
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- W2006075304 doi "https://doi.org/10.1016/s0040-4020(97)01024-7" @default.
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