FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006087142> ?p ?o ?g. }

• W2006087142 endingPage "6833" @default.
• W2006087142 startingPage "6833" @default.
• W2006087142 abstract "We present a generally applicable approach for monitoring protein aggregation by detecting changes in surface hydration water dynamics and the changes in solvent accessibility of specific protein sites, as protein aggregation proceeds in solution state. This is made possible through the Overhauser dynamic nuclear polarization (DNP) of water interacting with stable nitroxide spin labels tethered to specific proteins sites. This effect is highly localized due to the magnetic dipolar nature of the electron-proton spin interaction, with >80% of their interaction occurring within 5 A between the unpaired electron of the spin label and the proton of water. We showcase our tool on the aggregation of tau proteins, whose fibrillization is linked to neurodegenerative disease pathologies known as taupathies. We demonstrate that the DNP approach to monitor local changes in hydration dynamics with residue specificity and local contrast can distinguish specific and neat protein-protein packing leading to fibers from non-specific protein agglomeration or precipitation. The ability to monitor tau assembly with local, residue-specific, resolution, under ambient conditions and in solution state will help unravel the mechanism and structural characteristics of the gradual process of tau aggregation into amyloid fibers, which remains unclear to this day." @default.
• W2006087142 created "2016-06-24" @default.
• W2006087142 creator A5008615918 @default.
• W2006087142 creator A5022678474 @default.
• W2006087142 creator A5044573919 @default.
• W2006087142 creator A5048958731 @default.
• W2006087142 creator A5069882822 @default.
• W2006087142 creator A5072292956 @default.
• W2006087142 date "2009-01-01" @default.
• W2006087142 modified "2023-10-16" @default.
• W2006087142 title "Site-specific dynamic nuclear polarization of hydration water as a generally applicable approach to monitor protein aggregation" @default.
• W2006087142 cites W126369564 @default.
• W2006087142 cites W1970870837 @default.
• W2006087142 cites W1972683015 @default.
• W2006087142 cites W1986568955 @default.
• W2006087142 cites W1986700542 @default.
• W2006087142 cites W1988018591 @default.
• W2006087142 cites W1994282166 @default.
• W2006087142 cites W1994519311 @default.
• W2006087142 cites W1997241945 @default.
• W2006087142 cites W2008954354 @default.
• W2006087142 cites W2013416667 @default.
• W2006087142 cites W2014898742 @default.
• W2006087142 cites W2018908557 @default.
• W2006087142 cites W2028961200 @default.
• W2006087142 cites W2029904664 @default.
• W2006087142 cites W2033019961 @default.
• W2006087142 cites W2033682190 @default.
• W2006087142 cites W2034368626 @default.
• W2006087142 cites W2035598065 @default.
• W2006087142 cites W2059900570 @default.
• W2006087142 cites W2075813074 @default.
• W2006087142 cites W2077107650 @default.
• W2006087142 cites W2078462800 @default.
• W2006087142 cites W2079615523 @default.
• W2006087142 cites W2080074422 @default.
• W2006087142 cites W2086056683 @default.
• W2006087142 cites W2087924123 @default.
• W2006087142 cites W2091113012 @default.
• W2006087142 cites W2091441518 @default.
• W2006087142 cites W2096068783 @default.
• W2006087142 cites W2115015599 @default.
• W2006087142 cites W2124019813 @default.
• W2006087142 cites W2133622275 @default.
• W2006087142 cites W2155720843 @default.
• W2006087142 cites W2213843365 @default.
• W2006087142 doi "https://doi.org/10.1039/b906101k" @default.
• W2006087142 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3153360" @default.
• W2006087142 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19639158" @default.
• W2006087142 hasPublicationYear "2009" @default.
• W2006087142 type Work @default.
• W2006087142 sameAs 2006087142 @default.
• W2006087142 citedByCount "39" @default.
• W2006087142 countsByYear W20060871422012 @default.
• W2006087142 countsByYear W20060871422013 @default.
• W2006087142 countsByYear W20060871422014 @default.
• W2006087142 countsByYear W20060871422015 @default.
• W2006087142 countsByYear W20060871422016 @default.
• W2006087142 countsByYear W20060871422017 @default.
• W2006087142 countsByYear W20060871422019 @default.
• W2006087142 countsByYear W20060871422020 @default.
• W2006087142 countsByYear W20060871422021 @default.
• W2006087142 countsByYear W20060871422022 @default.
• W2006087142 crossrefType "journal-article" @default.
• W2006087142 hasAuthorship W2006087142A5008615918 @default.
• W2006087142 hasAuthorship W2006087142A5022678474 @default.
• W2006087142 hasAuthorship W2006087142A5044573919 @default.
• W2006087142 hasAuthorship W2006087142A5048958731 @default.
• W2006087142 hasAuthorship W2006087142A5069882822 @default.
• W2006087142 hasAuthorship W2006087142A5072292956 @default.
• W2006087142 hasBestOaLocation W20060871422 @default.
• W2006087142 hasConcept C121332964 @default.
• W2006087142 hasConcept C12554922 @default.
• W2006087142 hasConcept C136238340 @default.
• W2006087142 hasConcept C159467904 @default.
• W2006087142 hasConcept C177462420 @default.
• W2006087142 hasConcept C185592680 @default.
• W2006087142 hasConcept C2780471494 @default.
• W2006087142 hasConcept C41625074 @default.
• W2006087142 hasConcept C47701112 @default.
• W2006087142 hasConcept C54516573 @default.
• W2006087142 hasConcept C55493867 @default.
• W2006087142 hasConcept C62520636 @default.
• W2006087142 hasConcept C86803240 @default.
• W2006087142 hasConceptScore W2006087142C121332964 @default.
• W2006087142 hasConceptScore W2006087142C12554922 @default.
• W2006087142 hasConceptScore W2006087142C136238340 @default.
• W2006087142 hasConceptScore W2006087142C159467904 @default.
• W2006087142 hasConceptScore W2006087142C177462420 @default.
• W2006087142 hasConceptScore W2006087142C185592680 @default.
• W2006087142 hasConceptScore W2006087142C2780471494 @default.
• W2006087142 hasConceptScore W2006087142C41625074 @default.
• W2006087142 hasConceptScore W2006087142C47701112 @default.
• W2006087142 hasConceptScore W2006087142C54516573 @default.
• W2006087142 hasConceptScore W2006087142C55493867 @default.
• W2006087142 hasConceptScore W2006087142C62520636 @default.
• W2006087142 hasConceptScore W2006087142C86803240 @default.
• W2006087142 hasIssue "31" @default.

• next