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• W2006088637 abstract "Mice of 129/7 and C57BL/6J inbred strains received two-bottle, 48-h preference tests of NaCl solutions vs. distilled water. 129/J mice exhibited a greater preference for 0.08 M NaCl than did C57BL/ 6J mice. To determine if this strain difference was mediated by taste, the integrated neural responses of the chorda tympani nerve to a concentration range of NaCl and KCI were examined. Gustatory neural responses to NaCl were similar for 129/J and C57BL/ 6J mice. However, lingual application of 0.5 mM amiloride hydrochloride significantly suppressed chorda tympani responses to a range of NaCl concentrations in C57BL/6J mice but did not do so consistently in 129/J mice. Amiloride failed to significantly suppress responses to a range of KC1 concentrations in both mouse strains. The results suggest that for 129/J mice, sodium reception and transduction are primarily amiloride insensitive, whereas for C57BL/6J mice, both amiloride-sensitive and amiloride-insensitive components are present. The strain difference in NaCl intake may be mediated, in part, through gustatory mechanisms, with reduced preference for NaCl influenced by amiloride-sensitive sodium transduction mechanisms." @default.
• W2006088637 created "2016-06-24" @default.
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• W2006088637 date "1995-02-01" @default.
• W2006088637 modified "2023-10-18" @default.
• W2006088637 title "Sodium intake linked to amiloride-sensitive gustatory transduction in C57BL/6J and 129/7 mice" @default.
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• W2006088637 doi "https://doi.org/10.1016/0031-9384(94)00279-e" @default.
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