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• W2006095007 abstract "ABSTRACT Mannosylphosphorylation of N- and O-glycans, which confers negative charges on the surfaces of cells, requires the functions of both MNN4 and MNN6 in Saccharomyces cerevisiae . To identify genes relevant to mannosylphosphorylation in the dimorphic yeast Yarrowia lipolytica , the molecular functions of five Y. lipolytica genes showing significant sequence homology with S. cerevisiae MNN4 and MNN6 were investigated. A set of mutant strains in which Y. lipolytica MNN4 and MNN6 homologues were deleted underwent glycan structure analysis. In contrast to S. cerevisiae MNN4 (Sc MNN4 ), the Y. lipolytica MNN4 homologue, MPO1 (Yl MPO1 ), encodes a protein that lacks the long KKKKEEEE repeat domain at its C terminus. Moreover, just a single disruption of Yl MPO1 resulted in complete disappearance of the acidic sugar moiety in both the N- and O-linked glycan profiles. In contrast, even quadruple disruption of all Sc MNN6 homologues, designated Yl KTR1 , Yl KTR2 , Yl KTR3 , and Yl KTR4 , resulted in no apparent reduction in acidic sugar moieties. These findings strongly indicate that YlMpo1p performs a significant role in mannosylphosphorylation in Y. lipolytica with no involvement of the Mnn6p homologues. Mutant strains harboring the Yl MPO1 gene disruption may serve as useful platforms for engineering Y. lipolytica glycosylation pathways for humanized glycans without any yeast-specific acidic modifications." @default.
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• W2006095007 date "2011-02-15" @default.
• W2006095007 modified "2023-10-14" @default.
• W2006095007 title "Essential Role of Yl <i>MPO1</i> , a Novel <i>Yarrowia lipolytica</i> Homologue of <i>Saccharomyces cerevisiae MNN4</i> , in Mannosylphosphorylation of N- and O-Linked Glycans" @default.
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• W2006095007 doi "https://doi.org/10.1128/aem.02323-10" @default.
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