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• W2006095323 abstract "Human intercellular adhesion molecule-1 (ICAM-1), a specific ligand for the lymphocyte-function-associated antigen-1, plays an important role in immune responses. ICAM-I expression is regulated by various proinflammatory cytokines, by PMA, and by retinoic acid. In this study, we have investigated the mechanisms of transcriptional control involved in the stimulation of ICAM-I gene expression by retinoic acid in SK-N-SH cells. Northern-blot analysis demonstrated that ICAM-I mRNA is maximally induced at 24 hr, suggesting that it is not an early-response gene with respect to retinoic-acid responsiveness, whereas the retinoic acid receptorβ mRNA level was maximal 12 hr following retinoic acid treatment. To analyze the 5′-regulatory region of the ICAM-I gene, an EcoRI/Sall fragment spanning the first 1.3 kb upstream of the translational start site was used to direct the expression of a linked luciferase reporter gene in transient transaction assays in SK-N-SH cells. A 24-hr treatment of transfected cells with 10μ retinoic acid resulted in a 10- to 13-fold increase in luciferase activity compared with untreated cells. Deletion mutant analysis revealed that a region located between -393 and - 176 bp from the translational start site is critical for retinoic acid stimulation of luciferase activity. This region harbors a consensus sequence for a retinoic-acid-responsive element (RARE) homologous to the element found upstream of the alcohol dehydrogenase-3 gene. Co-transfection of expression vectors encoding the retinoic acid receptor-α, -β, or -γ, with reporter plasmids harboring the putative RARE, confirmed that the ICAM-I gene is regulated by retinoic acid in a retinoic acid receptor-dependent fashion." @default.
• W2006095323 created "2016-06-24" @default.
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• W2006095323 date "1994-08-15" @default.
• W2006095323 modified "2023-10-14" @default.
• W2006095323 title "Regulation of intercellular adhesion molecule-1 expression by retinoic acid: Analysis of the 5′ regulatory region of the gene" @default.
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• W2006095323 doi "https://doi.org/10.1002/ijc.2910580416" @default.
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