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- W2006098688 abstract "Background —Modeling of the time-[1- 11 C]acetate activity curve assumes a constant concentration of labeled tricarboxylic acid cycle intermediates and associated metabolites, such as glutamate and aspartate, which may, however, decrease in short-term hibernating myocardium. Methods and Results —In 12 anesthetized pigs, [1- 11 C]acetate was injected as a bolus into the cannulated left anterior descending coronary artery during normoperfusion, inotropic stimulation, and early (5 to 45 minutes) and prolonged ischemia (60 to 90 minutes). Regional myocardial oxygen consumption (MV̇ o 2 , microliters per minute per gram) was measured, and the absence of necrosis was verified by triphenyl tetrazolium chloride staining. Inotropic stimulation increased MV̇ o 2 from 52.5±7.4 to 195.4±36.2 (mean±SD) and the rate constant (k mono , minutes −1 ) of [1- 11 C]acetate clearance from 0.094±0.018 to 0.322±0.076. During early ischemia, MV̇ o 2 and k mono were decreased to 24.3±8.5 and 0.061±0.011, respectively. K mono closely correlated to MV̇ o 2 during normoperfusion, inotropic stimulation, and early ischemia. In short-term hibernating myocardium, however, at an unchanged MV̇ o 2 , k mono increased toward control values (0.080±0.014). Myocardial glutamate and aspartate concentrations (biopsies) decreased to 47±26% and 77±18%; the peak count rate decreased to 66±22% of its respective control value. After correction for the decreases in glutamate and aspartate or in peak count rate, k mono was again decreased (0.050±0.016 or 0.052±0.014, respectively), and a close relationship to MV̇ o 2 was restored. Conclusions —K mono correlates to MV̇ o 2 in short-term hibernating myocardium when the decreases in aspartate and glutamate or in peak count rate are considered." @default.
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- W2006098688 title "Positron Emission Tomography Analysis of [1- <sup>11</sup> C]Acetate Kinetics in Short-term Hibernating Myocardium" @default.
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- W2006098688 doi "https://doi.org/10.1161/01.cir.97.10.1009" @default.
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