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- W2006099430 endingPage "1020" @default.
- W2006099430 startingPage "1017" @default.
- W2006099430 abstract "Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal neurons during aging. However, the molecular basis for this elevation is not known. The partially dissociated hippocampal (zipper) slice preparation was used to analyze single Ca2+ channel activity in CA1 neurons of adult and aged rats. Total L-type Ca2+ channel activity in patches was found to increase with aging, primarily because of an increase in the density of functional channels. Learning in aged animals was inversely correlated with channel density. This increase in functional Ca2+ channels with aging could underlie the vulnerability of neurons to age-associated neurodegenerative conditions." @default.
- W2006099430 created "2016-06-24" @default.
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- W2006099430 date "1996-05-17" @default.
- W2006099430 modified "2023-10-14" @default.
- W2006099430 title "Increase in Single L-Type Calcium Channels in Hippocampal Neurons During Aging" @default.
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- W2006099430 doi "https://doi.org/10.1126/science.272.5264.1017" @default.
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