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• W2006101516 abstract "Abstract Rsm28p is a dispensable component of the mitochondrial ribosomal small subunit in Saccharomyces cerevisiae that is not related to known proteins found in bacteria. It was identified as a dominant suppressor of certain mitochondrial mutations that reduced translation of the COX2 mRNA. To explore further the function of Rsm28p, we isolated mutations in other genes that caused a synthetic respiratory defective phenotype together with rsm28Δ. These mutations identified three nuclear genes: IFM1, which encodes the mitochondrial translation initiation factor 2 (IF2); FMT1, which encodes the methionyl-tRNA-formyltransferase; and RMD9, a gene of unknown function. The observed genetic interactions strongly suggest that the ribosomal protein Rsm28p and Ifm1p (IF2) have similar and partially overlapping functions in yeast mitochondrial translation initiation. Rmd9p, bearing a TAP-tag, was localized to mitochondria and exhibited roughly equal distribution in soluble and membrane-bound fractions. A small fraction of the Rmd9-TAP sedimented together with presumed monosomes, but not with either individual ribosomal subunit. Thus, Rmd9 is not a ribosomal protein, but may be a novel factor associated with initiating monosomes. The poorly respiring rsm28Δ, rmd9-V363I double mutant did not have a strong translation-defective phenotype, suggesting that Rmd9p may function upstream of translation initiation, perhaps at the level of localization of mitochondrially coded mRNAs." @default.
• W2006101516 created "2016-06-24" @default.
• W2006101516 creator A5011120941 @default.
• W2006101516 creator A5019293145 @default.
• W2006101516 creator A5028595154 @default.
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• W2006101516 date "2007-03-01" @default.
• W2006101516 modified "2023-09-26" @default.
• W2006101516 title "Translation Initiation in <i>Saccharomyces cerevisiae</i> Mitochondria: Functional Interactions Among Mitochondrial Ribosomal Protein Rsm28p, Initiation Factor 2, Methionyl-tRNA-Formyltransferase and Novel Protein Rmd9p" @default.
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• W2006101516 doi "https://doi.org/10.1534/genetics.106.064576" @default.
• W2006101516 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1840066" @default.
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