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• W2006101631 abstract "Abstract A biodegradable drug delivery system containing 5% sanguinarium (Sa) was compared to vehicle control (VC), scaling and root planing (SRP). and supragingival plaque control (SPC) in the treatment of adult periodontitis in 2 well-controlled clinical trials. Studies were 4-quadrant (split mouth) designs at 2 centers each, having 94 (Study A) and 107 (Study B) patients. All patients had at least 3 pockets between 5 and 9 mm that bled on probing, in each quadrant. Probing pocket depth (PD), clinical attachment level (AL), bleeding on probing (BOP), and plaque index were recorded at baseline, 14, 30, 60, and 90 days. All treatments gave statistically significant reductions from baseline for PD and BOP. and significant gains for AL. For PD reduction. SRP was superior to all test groups at all time points in both studies (p < 0.001). Sa was superior to VC in Study A at 14 and 30 days and to SPC at all time points. For AL gain at 90 days, in both studies. SRP gave gains of 0.42 and 0.78 mm respectively with superiority seen over the SPC group at 90 days (p<0.001) in study A only. For BOP reduction, in Study A SRP was superior to Sa. VC. and SPC at 60 and 90 days (p<0.005) and in Study B superiority to Sa and VC was at 90 days and to SPC at 60 days (p<0.05). Sa was superior to VC for pocket depth in deep pockets only. Sa failed to demonstrate superiority over VC on a consistent basis. Analysis of residual Sa indicates that Sa potency was insufficient to show an advantage beyond clinical effects inherent in treatments with VC and SPC." @default.
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• W2006101631 date "1996-08-01" @default.
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• W2006101631 title "2 multi-center trials assessing the clinical efficacy of 5% sanguinarine in a biodegradable drug delivery system" @default.
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• W2006101631 doi "https://doi.org/10.1111/j.1600-051x.1996.tb00610.x" @default.
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