Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006101691> ?p ?o ?g. }
- W2006101691 endingPage "265" @default.
- W2006101691 startingPage "253" @default.
- W2006101691 abstract "Gastrulation in Caenorhabditis elegans is normally initiated by inward migration of the two gut precursor (E) cells at the 26-cell stage. A strong loss-of-function, temperature-sensitive, embryonic lethal mutation in the maternally required gene gad-1 (gastrulation defective) prevents gastrulation initiation. In embryos from homozygous mutant gad-1 (ct226) hermaphrodites reared at 25 degrees C, the E cells divide early with abnormal spindle orientations and fail to migrate into the embryo, and no subsequent gastrulation movements occur. These embryos continue to develop and differentiate the major cell types, but they undergo little morphogenesis. The temperature-sensitive period of the mutant is during early embryogenesis, prior to gastrulation onset. The predicted translation product of the cloned gad-1 gene includes six beta-transducin-related repeats of the WD motif, which has been implicated in protein-protein interactions. The ct226 mutation alters a conserved residue in one of these repeats. Injection of gad-1 antisense RNA into wild-type hermaphrodites mimics the mutant phenotype in progeny embryos. We conclude that the gad-1 gene product is required for initiation of gastrulation in C. elegans." @default.
- W2006101691 created "2016-06-24" @default.
- W2006101691 creator A5016317201 @default.
- W2006101691 creator A5073712959 @default.
- W2006101691 date "1998-06-01" @default.
- W2006101691 modified "2023-10-04" @default.
- W2006101691 title "Gastrulation initiation in Caenorhabditis elegans requires the function of gad-1, which encodes a protein with WD repeats" @default.
- W2006101691 cites W1679272024 @default.
- W2006101691 cites W1811130017 @default.
- W2006101691 cites W1834644249 @default.
- W2006101691 cites W1952115186 @default.
- W2006101691 cites W1956137678 @default.
- W2006101691 cites W1969714257 @default.
- W2006101691 cites W1973046803 @default.
- W2006101691 cites W1985591891 @default.
- W2006101691 cites W1989952069 @default.
- W2006101691 cites W1992194142 @default.
- W2006101691 cites W1997383129 @default.
- W2006101691 cites W2011124655 @default.
- W2006101691 cites W2015852214 @default.
- W2006101691 cites W2024204186 @default.
- W2006101691 cites W2025853097 @default.
- W2006101691 cites W2026068903 @default.
- W2006101691 cites W2030557396 @default.
- W2006101691 cites W2032769904 @default.
- W2006101691 cites W2039785559 @default.
- W2006101691 cites W2043647387 @default.
- W2006101691 cites W2047956518 @default.
- W2006101691 cites W2050072642 @default.
- W2006101691 cites W2052477009 @default.
- W2006101691 cites W2053702504 @default.
- W2006101691 cites W2062118692 @default.
- W2006101691 cites W2063023858 @default.
- W2006101691 cites W2064339093 @default.
- W2006101691 cites W2064352437 @default.
- W2006101691 cites W2064387879 @default.
- W2006101691 cites W2069723519 @default.
- W2006101691 cites W2071164795 @default.
- W2006101691 cites W2071399936 @default.
- W2006101691 cites W2095432731 @default.
- W2006101691 cites W2103108718 @default.
- W2006101691 cites W2107973236 @default.
- W2006101691 cites W2108880697 @default.
- W2006101691 cites W2115579737 @default.
- W2006101691 cites W2116402680 @default.
- W2006101691 cites W2117526699 @default.
- W2006101691 cites W2122163057 @default.
- W2006101691 cites W2136385924 @default.
- W2006101691 cites W2136449953 @default.
- W2006101691 cites W2154671341 @default.
- W2006101691 cites W2158595559 @default.
- W2006101691 cites W2168870153 @default.
- W2006101691 cites W2169009230 @default.
- W2006101691 cites W2186779150 @default.
- W2006101691 cites W237290622 @default.
- W2006101691 doi "https://doi.org/10.1016/s0012-1606(98)80003-1" @default.
- W2006101691 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9659931" @default.
- W2006101691 hasPublicationYear "1998" @default.
- W2006101691 type Work @default.
- W2006101691 sameAs 2006101691 @default.
- W2006101691 citedByCount "13" @default.
- W2006101691 countsByYear W20061016912020 @default.
- W2006101691 crossrefType "journal-article" @default.
- W2006101691 hasAuthorship W2006101691A5016317201 @default.
- W2006101691 hasAuthorship W2006101691A5073712959 @default.
- W2006101691 hasConcept C104317684 @default.
- W2006101691 hasConcept C129536746 @default.
- W2006101691 hasConcept C143065580 @default.
- W2006101691 hasConcept C153911025 @default.
- W2006101691 hasConcept C196843134 @default.
- W2006101691 hasConcept C2778944004 @default.
- W2006101691 hasConcept C54355233 @default.
- W2006101691 hasConcept C86803240 @default.
- W2006101691 hasConcept C87073359 @default.
- W2006101691 hasConcept C95444343 @default.
- W2006101691 hasConceptScore W2006101691C104317684 @default.
- W2006101691 hasConceptScore W2006101691C129536746 @default.
- W2006101691 hasConceptScore W2006101691C143065580 @default.
- W2006101691 hasConceptScore W2006101691C153911025 @default.
- W2006101691 hasConceptScore W2006101691C196843134 @default.
- W2006101691 hasConceptScore W2006101691C2778944004 @default.
- W2006101691 hasConceptScore W2006101691C54355233 @default.
- W2006101691 hasConceptScore W2006101691C86803240 @default.
- W2006101691 hasConceptScore W2006101691C87073359 @default.
- W2006101691 hasConceptScore W2006101691C95444343 @default.
- W2006101691 hasIssue "2" @default.
- W2006101691 hasLocation W20061016911 @default.
- W2006101691 hasLocation W20061016912 @default.
- W2006101691 hasOpenAccess W2006101691 @default.
- W2006101691 hasPrimaryLocation W20061016911 @default.
- W2006101691 hasRelatedWork W1809349505 @default.
- W2006101691 hasRelatedWork W1920402565 @default.
- W2006101691 hasRelatedWork W1946787458 @default.
- W2006101691 hasRelatedWork W2018729614 @default.
- W2006101691 hasRelatedWork W2039785559 @default.
- W2006101691 hasRelatedWork W2059594975 @default.
- W2006101691 hasRelatedWork W2125731289 @default.
- W2006101691 hasRelatedWork W2141084979 @default.