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- W2006110930 abstract "An efficient solid-phase synthesis of mono-N-substituted piperazines is presented. The key transformation involves a selective borane amide bond reduction in the presence of a carbamate resin linkage. This synthetic route takes advantage of the large diverse pool of commercially available carboxylic acids, acid chlorides, and sulfonyl chlorides. The solid-phase approach facilitates parallel processing by eliminating the need for column chromatography after each synthetic step. The N-monosubstituted piperazines were shown to react with polymeric activated tetrafluorophenol (TFP) reagents to generate arrays of amides and sulfonamides in good purity for biological testing." @default.
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- W2006110930 date "2003-02-15" @default.
- W2006110930 modified "2023-09-24" @default.
- W2006110930 title "The Solid-Phase Synthesis and Use of N-Monosubstituted Piperazines in Chemical Library Synthesis" @default.
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- W2006110930 doi "https://doi.org/10.1021/cc020060w" @default.
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