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- W2006125377 abstract "In this review of the mechanisms underlying pyrogenic tolerance to bacterial endotoxins, two earlier concepts require modification. (1) Granulocytes are the major source of endogenous pyrogen release by endotoxin. (2) Pyrogenic tolerance results simply from accelerated clearance of endotoxin by the reticuloendothelial system (RES), diverting the toxin from the granulocytes. Rather, it now appears that hepatic Kupffer cells are the major source of endogenous pyrogen release by endotoxin, and that pyrogenic tolerance results primarily from refractoriness of these cells to further release of endogenous pyrogen. Accelerated clearance by the RES appears to be an ancillary protective mechanism that brings toxin more rapidly to the refractory cells. Refractoriness to the release of endogenous pyrogen can be achieved both by direct cellular interaction with endotoxin and by antibodies to endotoxin. The direct cellular effect is transient and requires closely spaced injections of endotoxin for maximal maintenance; antibody-mediated protection is delayed but more enduring. The diverse, often conflicting observations on pyrogenic tolerance are explicable by the interplay of these protective mechanisms." @default.
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- W2006125377 title "Mechanisms of Endotoxin Tolerance with Special Reference to Man" @default.
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- W2006125377 doi "https://doi.org/10.1093/infdis/128.supplement_1.s265" @default.
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