Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006127996> ?p ?o ?g. }
- W2006127996 endingPage "238" @default.
- W2006127996 startingPage "229" @default.
- W2006127996 abstract "The classical mineralocorticoid effect of aldosterone on unidirectional transepithelial sodium transport in the kidney was long thought to be the predominant effect of this hormone. However, there is convincing evidence for additional extrarenal actions of aldosterone that are mediated via activation of mineralocorticoid receptors (MRs) in the heart, vasculature and brain. It is now postulated that many of the detrimental effects of aldosterone are mediated through MR activation in these nonclassical target organs. The selective aldosterone blocker, eplerenone (Inspra™), is under development for human therapeutic use for treatment of hypertension and heart failure post-myocardial infarction (MI). Clinical and preclinical studies have linked elevated aldosterone to hypertension, left ventricular and vascular remodeling, cardiac, renal, and cerebral vascular inflammation and injury, and increased risk of mortality in heart failure patients. Multiple studies in experimental models of hypertension and heart failure demonstrate that selective blockade of aldosterone by eplerenone effectively preserves cardiac function, attenuates maladaptive left ventricular remodeling and tissue and vascular injury in part by reducing vascular inflammation in aldosterone target organs." @default.
- W2006127996 created "2016-06-24" @default.
- W2006127996 creator A5016333383 @default.
- W2006127996 creator A5031816397 @default.
- W2006127996 creator A5036101225 @default.
- W2006127996 date "2004-03-01" @default.
- W2006127996 modified "2023-09-27" @default.
- W2006127996 title "Aldosterone target organ protection by eplerenone" @default.
- W2006127996 cites W1978501030 @default.
- W2006127996 cites W1985484574 @default.
- W2006127996 cites W1987089303 @default.
- W2006127996 cites W1997062534 @default.
- W2006127996 cites W2003989747 @default.
- W2006127996 cites W2005401474 @default.
- W2006127996 cites W2005806825 @default.
- W2006127996 cites W2005862934 @default.
- W2006127996 cites W2006910397 @default.
- W2006127996 cites W2017884988 @default.
- W2006127996 cites W2019216135 @default.
- W2006127996 cites W2023969397 @default.
- W2006127996 cites W2028760558 @default.
- W2006127996 cites W2031897773 @default.
- W2006127996 cites W2041064718 @default.
- W2006127996 cites W2059722418 @default.
- W2006127996 cites W2067094928 @default.
- W2006127996 cites W2069526546 @default.
- W2006127996 cites W2072546876 @default.
- W2006127996 cites W2074149689 @default.
- W2006127996 cites W2089392247 @default.
- W2006127996 cites W2090037917 @default.
- W2006127996 cites W2090621492 @default.
- W2006127996 cites W2096737170 @default.
- W2006127996 cites W2101652320 @default.
- W2006127996 cites W2114018836 @default.
- W2006127996 cites W2116965552 @default.
- W2006127996 cites W2123778248 @default.
- W2006127996 cites W2125226019 @default.
- W2006127996 cites W2127817669 @default.
- W2006127996 cites W2134730025 @default.
- W2006127996 cites W2136714451 @default.
- W2006127996 cites W2142803942 @default.
- W2006127996 cites W2147005862 @default.
- W2006127996 cites W2148114970 @default.
- W2006127996 cites W2148155169 @default.
- W2006127996 cites W2150053644 @default.
- W2006127996 cites W2152094259 @default.
- W2006127996 cites W2157756663 @default.
- W2006127996 cites W2184697404 @default.
- W2006127996 cites W2312388685 @default.
- W2006127996 cites W2323458614 @default.
- W2006127996 cites W2324101044 @default.
- W2006127996 cites W3022104346 @default.
- W2006127996 cites W4231659835 @default.
- W2006127996 cites W4243144188 @default.
- W2006127996 doi "https://doi.org/10.1016/j.mce.2003.10.047" @default.
- W2006127996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15134822" @default.
- W2006127996 hasPublicationYear "2004" @default.
- W2006127996 type Work @default.
- W2006127996 sameAs 2006127996 @default.
- W2006127996 citedByCount "55" @default.
- W2006127996 countsByYear W20061279962012 @default.
- W2006127996 countsByYear W20061279962013 @default.
- W2006127996 countsByYear W20061279962014 @default.
- W2006127996 countsByYear W20061279962015 @default.
- W2006127996 countsByYear W20061279962018 @default.
- W2006127996 countsByYear W20061279962019 @default.
- W2006127996 countsByYear W20061279962020 @default.
- W2006127996 countsByYear W20061279962021 @default.
- W2006127996 countsByYear W20061279962022 @default.
- W2006127996 crossrefType "journal-article" @default.
- W2006127996 hasAuthorship W2006127996A5016333383 @default.
- W2006127996 hasAuthorship W2006127996A5031816397 @default.
- W2006127996 hasAuthorship W2006127996A5036101225 @default.
- W2006127996 hasConcept C126322002 @default.
- W2006127996 hasConcept C134018914 @default.
- W2006127996 hasConcept C164705383 @default.
- W2006127996 hasConcept C170493617 @default.
- W2006127996 hasConcept C189135053 @default.
- W2006127996 hasConcept C2776069600 @default.
- W2006127996 hasConcept C2776379505 @default.
- W2006127996 hasConcept C2776914184 @default.
- W2006127996 hasConcept C2778198053 @default.
- W2006127996 hasConcept C2778468042 @default.
- W2006127996 hasConcept C2778525890 @default.
- W2006127996 hasConcept C2780072264 @default.
- W2006127996 hasConcept C71924100 @default.
- W2006127996 hasConceptScore W2006127996C126322002 @default.
- W2006127996 hasConceptScore W2006127996C134018914 @default.
- W2006127996 hasConceptScore W2006127996C164705383 @default.
- W2006127996 hasConceptScore W2006127996C170493617 @default.
- W2006127996 hasConceptScore W2006127996C189135053 @default.
- W2006127996 hasConceptScore W2006127996C2776069600 @default.
- W2006127996 hasConceptScore W2006127996C2776379505 @default.
- W2006127996 hasConceptScore W2006127996C2776914184 @default.
- W2006127996 hasConceptScore W2006127996C2778198053 @default.
- W2006127996 hasConceptScore W2006127996C2778468042 @default.
- W2006127996 hasConceptScore W2006127996C2778525890 @default.
- W2006127996 hasConceptScore W2006127996C2780072264 @default.