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• W2006129265 abstract "We build on our earlier quantum wavepacket study of hydrogen transfer in the biological enzyme soybean lipoxygenase-1 by using von Neumann quantum measurement theory to gain qualitative insights into the transfer event. We treat the enzyme active site as a measurement device which acts on the tunneling hydrogen nucleus via the potential it exerts at each configuration. A series of changing active site geometries during the tunneling process effects a sequential projection of the initial, reactant state onto the final, product state. We study this process using several different kinds of von Neumann measurements and show how a discrete sequence of such measurements not only progressively increases the projection of the hydrogen nuclear wavepacket onto the product side but also favors proton over deuteron transfer. Several qualitative features of the hydrogen tunneling problem found in wavepacket dynamics studies are also recovered here. These include the shift in the “transition state” toward the reactant as a result of nuclear quantization, greater participation of excited states in the case of deuterium, and the presence of critical points along the reaction coordinate that facilitate hydrogen and deuterium transfer and coincide with surface crossings. To further “tailor” the dynamics, we construct a perturbation to the sequence of measurements, that is a perturbation to the dynamical sequence of active site geometry evolution, which leads us to insight on the existence of sensitive regions of the reaction profile where subtle changes to the dynamics of the active site can have an effect on the hydrogen and deuterium transfer process." @default.
• W2006129265 created "2016-06-24" @default.
• W2006129265 creator A5016229922 @default.
• W2006129265 creator A5019081599 @default.
• W2006129265 date "2010-03-31" @default.
• W2006129265 modified "2023-10-18" @default.
• W2006129265 title "Analysis of Hydrogen Tunneling in an Enzyme Active Site Using von Neumann Measurements" @default.
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• W2006129265 cites W1964810656 @default.
• W2006129265 cites W1967800787 @default.
• W2006129265 cites W1981656241 @default.
• W2006129265 cites W1981694796 @default.
• W2006129265 cites W1982839983 @default.
• W2006129265 cites W1984876499 @default.
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• W2006129265 cites W1995917700 @default.
• W2006129265 cites W1996741045 @default.
• W2006129265 cites W1998455825 @default.
• W2006129265 cites W1999949048 @default.
• W2006129265 cites W2004303971 @default.
• W2006129265 cites W2008428704 @default.
• W2006129265 cites W2008609697 @default.
• W2006129265 cites W2009385089 @default.
• W2006129265 cites W2012330423 @default.
• W2006129265 cites W2012772821 @default.
• W2006129265 cites W2013410957 @default.
• W2006129265 cites W2016201075 @default.
• W2006129265 cites W2016468616 @default.
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• W2006129265 cites W2026008088 @default.
• W2006129265 cites W2027815611 @default.
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• W2006129265 cites W2047643592 @default.
• W2006129265 cites W2051631220 @default.
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• W2006129265 cites W2069262775 @default.
• W2006129265 cites W2069616023 @default.
• W2006129265 cites W2073915950 @default.
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• W2006129265 doi "https://doi.org/10.1021/ct900630n" @default.
• W2006129265 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3428049" @default.
• W2006129265 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22933858" @default.
• W2006129265 hasPublicationYear "2010" @default.
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