Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006129483> ?p ?o ?g. }
- W2006129483 endingPage "84" @default.
- W2006129483 startingPage "77" @default.
- W2006129483 abstract "Myalgias are the most common side effect of statin use and the commonest cause for discontinuing therapy. Vitamin D has known physiologic functions in muscle and vitamin D deficiency is known to cause myalgias, with its correction leading to disappearance of muscle symptoms. The 521T>C SLCO1B1*5 gene polymorphism decreasing function in the gene coding for a liver anion transporter that is responsible for statin uptake has been found to explain the majority of statin-associated muscle symptoms. Patients with statin-associated myalgias have been reported to improve with vitamin D supplementation. We therefore investigated i) whether repletion of vitamin D in deficient patients with myalgias could lead to tolerance for subsequent statin therapy, and ii) whether vitamin D status modifies the effect of the SLCO1B1*5 genotype on myalgia risk. Using a retrospective cohort of 64 patients in whom 25-hydroxyvitamin D [25(OH)D] had been measured for any reason while on statin therapy, including 46 patients who consented to be genotyped, we found strong evidence showing that repletion of vitamin D in vitamin D deficient patients improved myalgias. Of 21 vitamin D deficient patients with intolerable statin-associated myalgias, 14 of 15 rechallenged with statins were subsequently symptom-free, with one patient experiencing mild and tolerable symptoms, far exceeding expected rates of acquired tolerability with no therapy (p=0.01). In addition, while the SLCO1B1*5 genotype was associated with a 3-fold increased risk of myalgias (p=0.07), this risk was not found to differ by vitamin D status (p=0.60)." @default.
- W2006129483 created "2016-06-24" @default.
- W2006129483 creator A5022644052 @default.
- W2006129483 creator A5032969374 @default.
- W2006129483 creator A5036496348 @default.
- W2006129483 creator A5085486302 @default.
- W2006129483 date "2010-04-01" @default.
- W2006129483 modified "2023-10-04" @default.
- W2006129483 title "The role of vitamin D and SLCO1B1 gene polymorphism in statin-associated myalgias" @default.
- W2006129483 cites W150250458 @default.
- W2006129483 cites W1604547439 @default.
- W2006129483 cites W176130219 @default.
- W2006129483 cites W1972231896 @default.
- W2006129483 cites W1974928646 @default.
- W2006129483 cites W1982499176 @default.
- W2006129483 cites W1985565845 @default.
- W2006129483 cites W1990993346 @default.
- W2006129483 cites W2018868115 @default.
- W2006129483 cites W2024277698 @default.
- W2006129483 cites W2024936844 @default.
- W2006129483 cites W2026961817 @default.
- W2006129483 cites W2031556182 @default.
- W2006129483 cites W2035139971 @default.
- W2006129483 cites W2036888384 @default.
- W2006129483 cites W2053130595 @default.
- W2006129483 cites W2059078444 @default.
- W2006129483 cites W2064896297 @default.
- W2006129483 cites W2065237107 @default.
- W2006129483 cites W2079789436 @default.
- W2006129483 cites W2099665543 @default.
- W2006129483 cites W2103873642 @default.
- W2006129483 cites W2111343462 @default.
- W2006129483 cites W2124070987 @default.
- W2006129483 cites W2127457459 @default.
- W2006129483 cites W2131288319 @default.
- W2006129483 cites W2131552966 @default.
- W2006129483 cites W2139681313 @default.
- W2006129483 cites W2140314600 @default.
- W2006129483 cites W2148546401 @default.
- W2006129483 cites W2151244893 @default.
- W2006129483 cites W2157482325 @default.
- W2006129483 cites W2160936671 @default.
- W2006129483 cites W2166471219 @default.
- W2006129483 cites W2170643508 @default.
- W2006129483 cites W2207307625 @default.
- W2006129483 cites W24049057 @default.
- W2006129483 cites W2727742003 @default.
- W2006129483 cites W3022181047 @default.
- W2006129483 cites W4239262829 @default.
- W2006129483 cites W4243096964 @default.
- W2006129483 doi "https://doi.org/10.4161/derm.2.2.13509" @default.
- W2006129483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3081682" @default.
- W2006129483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21547103" @default.
- W2006129483 hasPublicationYear "2010" @default.
- W2006129483 type Work @default.
- W2006129483 sameAs 2006129483 @default.
- W2006129483 citedByCount "41" @default.
- W2006129483 countsByYear W20061294832012 @default.
- W2006129483 countsByYear W20061294832013 @default.
- W2006129483 countsByYear W20061294832014 @default.
- W2006129483 countsByYear W20061294832015 @default.
- W2006129483 countsByYear W20061294832016 @default.
- W2006129483 countsByYear W20061294832017 @default.
- W2006129483 countsByYear W20061294832018 @default.
- W2006129483 countsByYear W20061294832019 @default.
- W2006129483 countsByYear W20061294832020 @default.
- W2006129483 countsByYear W20061294832021 @default.
- W2006129483 countsByYear W20061294832022 @default.
- W2006129483 countsByYear W20061294832023 @default.
- W2006129483 crossrefType "journal-article" @default.
- W2006129483 hasAuthorship W2006129483A5022644052 @default.
- W2006129483 hasAuthorship W2006129483A5032969374 @default.
- W2006129483 hasAuthorship W2006129483A5036496348 @default.
- W2006129483 hasAuthorship W2006129483A5085486302 @default.
- W2006129483 hasBestOaLocation W20061294831 @default.
- W2006129483 hasConcept C104317684 @default.
- W2006129483 hasConcept C124490489 @default.
- W2006129483 hasConcept C126322002 @default.
- W2006129483 hasConcept C134018914 @default.
- W2006129483 hasConcept C135763542 @default.
- W2006129483 hasConcept C167135981 @default.
- W2006129483 hasConcept C197934379 @default.
- W2006129483 hasConcept C2776598434 @default.
- W2006129483 hasConcept C2776839432 @default.
- W2006129483 hasConcept C2776940978 @default.
- W2006129483 hasConcept C2778375690 @default.
- W2006129483 hasConcept C2778616394 @default.
- W2006129483 hasConcept C2779740938 @default.
- W2006129483 hasConcept C2779819292 @default.
- W2006129483 hasConcept C55493867 @default.
- W2006129483 hasConcept C55775858 @default.
- W2006129483 hasConcept C71924100 @default.
- W2006129483 hasConcept C72563966 @default.
- W2006129483 hasConcept C86803240 @default.
- W2006129483 hasConcept C90924648 @default.
- W2006129483 hasConceptScore W2006129483C104317684 @default.
- W2006129483 hasConceptScore W2006129483C124490489 @default.
- W2006129483 hasConceptScore W2006129483C126322002 @default.