FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006132562> ?p ?o ?g. }

• W2006132562 abstract "The capacity of the pituitary to suppress hormone secretion in response to somatostatin (SRIF) is markedly age dependent. Immature pituitaries are relatively resistant to SRIF effects, and increasing sensitivity to SRIF with advancing age is believed to cause characteristic developmental changes in pituitary hormone secretion in mammals. However, the cellular mechanism(s) underlying this developmental pattern of response to SRIF are not understood. Because somatostatin receptors (ssts) are critical mediators of SRIF's actions on target tissues, we investigated the expression of sst1, sst2, sst3, sst4, and sst5 messenger RNA (mRNA) in pituitaries of developing and mature rats. Animals were studied at embryonic day 19.5, and at postnatal days 2, 12, 30, 45, 70, and 1 yr; these ages correspond to major changes in circulating GH levels and pituitary responsiveness to SRIF. Pituitary levels of sst2 mRNA increased strikingly and progressively with advancing age after birth (F = 30.92, P < 0.0001). Compared with 2-day-old pituitaries, sst2 mRNA abundance rose 3.25-fold by 12 days of age and 6-fold by 70 days of age. Moreover, Western blot analysis indicated a marked increase in pituitary expression of sst2A protein with advancing age. By contrast, pituitary abundance of sst1, sst3, sst4, and sst5 mRNAs did not differ with age. To assess the role of endogenous SRIF in regulating perinatal sst2 gene expression, we also administered a well-characterized SRIF antiserum (or NSS as controls; 10 microl/10 g) sc daily from postnatal days 2 to 12 of life. Treatment with SRIF antiserum raised GH levels but did not alter pituitary sst2 mRNA abundance, compared with controls. Taken together, these data indicate that 1) the perinatal rat pituitary expresses the same complement of ssts as the adult pituitary; 2) expression of ssts is developmentally regulated in a highly subtype-specific manner; 3) pituitary sst2 mRNA and sst2A protein increase markedly and progressively with advancing age after birth; and 4) the perinatal rise in sst2 mRNA levels is unlikely to be regulated by endogenous SRIF. The finding of subtype-specific, developmentally determined sst expression indicates a novel and potentially fundamental mechanism of sst regulation, and suggests a molecular mechanism underlying developmental maturation in the capacity of the pituitary to respond to SRIF." @default.
• W2006132562 created "2016-06-24" @default.
• W2006132562 creator A5006839991 @default.
• W2006132562 creator A5041927815 @default.
• W2006132562 creator A5049641886 @default.
• W2006132562 creator A5079359873 @default.
• W2006132562 creator A5083601351 @default.
• W2006132562 creator A5087891732 @default.
• W2006132562 date "1999-10-01" @default.
• W2006132562 modified "2023-10-02" @default.
• W2006132562 title "Pituitary Somatostatin Receptor (sst)1–5 Expression during Rat Development: Age-Dependent Expression of sst21" @default.
• W2006132562 cites W1579943994 @default.
• W2006132562 cites W1594960037 @default.
• W2006132562 cites W1967142752 @default.
• W2006132562 cites W1968374564 @default.
• W2006132562 cites W1971346575 @default.
• W2006132562 cites W1976542588 @default.
• W2006132562 cites W1980125762 @default.
• W2006132562 cites W1987910229 @default.
• W2006132562 cites W1992284590 @default.
• W2006132562 cites W1993231398 @default.
• W2006132562 cites W1993827955 @default.
• W2006132562 cites W1994794562 @default.
• W2006132562 cites W1995733656 @default.
• W2006132562 cites W1997993870 @default.
• W2006132562 cites W1998409562 @default.
• W2006132562 cites W1998795762 @default.
• W2006132562 cites W2002389632 @default.
• W2006132562 cites W2005821299 @default.
• W2006132562 cites W2009944454 @default.
• W2006132562 cites W2019237011 @default.
• W2006132562 cites W2029324208 @default.
• W2006132562 cites W2029951484 @default.
• W2006132562 cites W2030462330 @default.
• W2006132562 cites W2031484426 @default.
• W2006132562 cites W2032069357 @default.
• W2006132562 cites W2032511791 @default.
• W2006132562 cites W2032515982 @default.
• W2006132562 cites W2034111999 @default.
• W2006132562 cites W2036030594 @default.
• W2006132562 cites W2049287362 @default.
• W2006132562 cites W2049648399 @default.
• W2006132562 cites W2054488979 @default.
• W2006132562 cites W2057501272 @default.
• W2006132562 cites W2058508589 @default.
• W2006132562 cites W2060165461 @default.
• W2006132562 cites W2065131235 @default.
• W2006132562 cites W2066299256 @default.
• W2006132562 cites W2066524003 @default.
• W2006132562 cites W2071200106 @default.
• W2006132562 cites W2075317954 @default.
• W2006132562 cites W2075477641 @default.
• W2006132562 cites W2075910471 @default.
• W2006132562 cites W2077054785 @default.
• W2006132562 cites W2079379846 @default.
• W2006132562 cites W2085071900 @default.
• W2006132562 cites W2090420969 @default.
• W2006132562 cites W2103233430 @default.
• W2006132562 cites W2114647361 @default.
• W2006132562 cites W2124330263 @default.
• W2006132562 cites W2131690895 @default.
• W2006132562 cites W2134812217 @default.
• W2006132562 cites W2143517945 @default.
• W2006132562 cites W2160694019 @default.
• W2006132562 cites W2165599173 @default.
• W2006132562 cites W2166935415 @default.
• W2006132562 cites W2399619188 @default.
• W2006132562 cites W597918840 @default.
• W2006132562 cites W2095216044 @default.
• W2006132562 cites W2138476062 @default.
• W2006132562 doi "https://doi.org/10.1210/endo.140.10.7033" @default.
• W2006132562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10499533" @default.
• W2006132562 hasPublicationYear "1999" @default.
• W2006132562 type Work @default.
• W2006132562 sameAs 2006132562 @default.
• W2006132562 citedByCount "28" @default.
• W2006132562 countsByYear W20061325622012 @default.
• W2006132562 countsByYear W20061325622013 @default.
• W2006132562 countsByYear W20061325622015 @default.
• W2006132562 countsByYear W20061325622017 @default.
• W2006132562 countsByYear W20061325622018 @default.
• W2006132562 countsByYear W20061325622019 @default.
• W2006132562 crossrefType "journal-article" @default.
• W2006132562 hasAuthorship W2006132562A5006839991 @default.
• W2006132562 hasAuthorship W2006132562A5041927815 @default.
• W2006132562 hasAuthorship W2006132562A5049641886 @default.
• W2006132562 hasAuthorship W2006132562A5079359873 @default.
• W2006132562 hasAuthorship W2006132562A5083601351 @default.
• W2006132562 hasAuthorship W2006132562A5087891732 @default.
• W2006132562 hasBestOaLocation W20061325621 @default.
• W2006132562 hasConcept C104317684 @default.
• W2006132562 hasConcept C105580179 @default.
• W2006132562 hasConcept C118303440 @default.
• W2006132562 hasConcept C126322002 @default.
• W2006132562 hasConcept C134018914 @default.
• W2006132562 hasConcept C150008808 @default.
• W2006132562 hasConcept C170493617 @default.
• W2006132562 hasConcept C2776297358 @default.
• W2006132562 hasConcept C2777658017 @default.
• W2006132562 hasConcept C2779029589 @default.

• next