Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006133064> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2006133064 endingPage "38a" @default.
- W2006133064 startingPage "38a" @default.
- W2006133064 abstract "Kinesin-8 is a highly processive plus-end directed motor protein that is conserved in eukaryotes from yeast to human. Different members of the Kinesin-8 family have been shown in vivo to control the length of microtubules by interacting with their plus ends. High processivity is crucial for these motors to reach the microtubule plus ends, where they induce catastrophes or otherwise interfere with microtubule dynamics. In this study, we characterized yeast (Kip3) and human (Kif18A) kinesin-8s using optical tweezers. Both kinesin-8 motors stalled under load forces of only ∼1 pN, much less than the stall forces measured for other kinesins. Furthermore, we found that higher load forces caused the motor to slip backwards on the microtubule towards the minus end; the motor could recover from this state and resume plus-end motility. The low forces are consistent with kinesin-8s being regulators of microtubule dynamics rather than cargo transporters; the slip state, in which the motor remains in a weakly bound state, may be an adaptation for high processivity." @default.
- W2006133064 created "2016-06-24" @default.
- W2006133064 creator A5041402911 @default.
- W2006133064 creator A5073902697 @default.
- W2006133064 creator A5081060062 @default.
- W2006133064 creator A5086267534 @default.
- W2006133064 date "2012-01-01" @default.
- W2006133064 modified "2023-09-30" @default.
- W2006133064 title "Kinesin-8 is a Weak Motor Protein with a Weakly Bound Slip State" @default.
- W2006133064 doi "https://doi.org/10.1016/j.bpj.2011.11.234" @default.
- W2006133064 hasPublicationYear "2012" @default.
- W2006133064 type Work @default.
- W2006133064 sameAs 2006133064 @default.
- W2006133064 citedByCount "0" @default.
- W2006133064 crossrefType "journal-article" @default.
- W2006133064 hasAuthorship W2006133064A5041402911 @default.
- W2006133064 hasAuthorship W2006133064A5073902697 @default.
- W2006133064 hasAuthorship W2006133064A5081060062 @default.
- W2006133064 hasAuthorship W2006133064A5086267534 @default.
- W2006133064 hasBestOaLocation W20061330641 @default.
- W2006133064 hasConcept C105480513 @default.
- W2006133064 hasConcept C121332964 @default.
- W2006133064 hasConcept C12554922 @default.
- W2006133064 hasConcept C131140672 @default.
- W2006133064 hasConcept C160408235 @default.
- W2006133064 hasConcept C20198109 @default.
- W2006133064 hasConcept C20418707 @default.
- W2006133064 hasConcept C54355233 @default.
- W2006133064 hasConcept C552990157 @default.
- W2006133064 hasConcept C59006786 @default.
- W2006133064 hasConcept C62520636 @default.
- W2006133064 hasConcept C73573662 @default.
- W2006133064 hasConcept C86803240 @default.
- W2006133064 hasConcept C93126451 @default.
- W2006133064 hasConcept C95444343 @default.
- W2006133064 hasConceptScore W2006133064C105480513 @default.
- W2006133064 hasConceptScore W2006133064C121332964 @default.
- W2006133064 hasConceptScore W2006133064C12554922 @default.
- W2006133064 hasConceptScore W2006133064C131140672 @default.
- W2006133064 hasConceptScore W2006133064C160408235 @default.
- W2006133064 hasConceptScore W2006133064C20198109 @default.
- W2006133064 hasConceptScore W2006133064C20418707 @default.
- W2006133064 hasConceptScore W2006133064C54355233 @default.
- W2006133064 hasConceptScore W2006133064C552990157 @default.
- W2006133064 hasConceptScore W2006133064C59006786 @default.
- W2006133064 hasConceptScore W2006133064C62520636 @default.
- W2006133064 hasConceptScore W2006133064C73573662 @default.
- W2006133064 hasConceptScore W2006133064C86803240 @default.
- W2006133064 hasConceptScore W2006133064C93126451 @default.
- W2006133064 hasConceptScore W2006133064C95444343 @default.
- W2006133064 hasIssue "3" @default.
- W2006133064 hasLocation W20061330641 @default.
- W2006133064 hasOpenAccess W2006133064 @default.
- W2006133064 hasPrimaryLocation W20061330641 @default.
- W2006133064 hasRelatedWork W1963716975 @default.
- W2006133064 hasRelatedWork W1976934749 @default.
- W2006133064 hasRelatedWork W1978376377 @default.
- W2006133064 hasRelatedWork W2005595627 @default.
- W2006133064 hasRelatedWork W2011324298 @default.
- W2006133064 hasRelatedWork W2043823852 @default.
- W2006133064 hasRelatedWork W2055750084 @default.
- W2006133064 hasRelatedWork W2066047379 @default.
- W2006133064 hasRelatedWork W2066974921 @default.
- W2006133064 hasRelatedWork W2071777531 @default.
- W2006133064 hasRelatedWork W2079834807 @default.
- W2006133064 hasRelatedWork W2088848199 @default.
- W2006133064 hasRelatedWork W2155004688 @default.
- W2006133064 hasRelatedWork W2170121030 @default.
- W2006133064 hasRelatedWork W2283388913 @default.
- W2006133064 hasRelatedWork W2427038789 @default.
- W2006133064 hasRelatedWork W2767751434 @default.
- W2006133064 hasRelatedWork W2887752908 @default.
- W2006133064 hasRelatedWork W2923931907 @default.
- W2006133064 hasRelatedWork W3010972328 @default.
- W2006133064 hasVolume "102" @default.
- W2006133064 isParatext "false" @default.
- W2006133064 isRetracted "false" @default.
- W2006133064 magId "2006133064" @default.
- W2006133064 workType "article" @default.