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• W2006137389 abstract "To study the effect of mitomycin C (MMC) on the corneal regrowth after laser-assisted sub-epithelial keratectomy (LASEK). We performed a prospective, controlled, observer-masked study of 64 consecutive eyes scheduled to undergo LASEK to correct their myopia. The patients were divided into two age-matched groups. With Group 1 including 32 eyes in which the ablation depth was ≤50 μm and received no MMC. Group 2 consisted of 32 eyes in which the ablation depth exceeded 50 μm and were treated with intra-operative 0.02% MMC for 30 s over the ablated zone. A masked observer measured the central corneal thickness (CCT) 1 and 3 months after surgery. We compared the change in CCT between both groups up to 3 months after surgery. The mean patient age was 31.5 years (SD 4.6) and 31.6 years (SD 8.7) in groups 1 and 2, respectively (p = 0.9). Group 1 showed a mean CCT of 444.0 (SD 41.3) μm one month after surgery and 450.3 (SD 43.5) μm three months after surgery (p = 0.04). CCT values in group 2 were 399.7 (SD 31.2) μm and 407.9 (SD 32.6) μm for one and three months after surgery, respectively (p = 0.006). The difference in the CCT increases between both groups was not statistically significant (p = 0.6). A single intraoperative application of 0.02% MMC for 30 seconds did not seem to cause a substantial change in the post-surgical corneal thickening expected after LASEK. Estudiar el efecto de la mitomicina C (MMC) en el engrosamiento corneal tras keratectomía subepitelial con láser excimer (LASEK). Realizamos un estudio prospectivo, controlado, enmascarado de 64 ojos consecutivos operados con LASEK para corregir su miopía. Separamos dos grupos empatados por edad. 32 ojos en los que la profundidad de ablación era ≤50 micras (μm) fueron incluidos en el grupo 1 y no recibieron MMC. 32 ojos en los que la profundidad de ablación era >50 μm se incluyeron en el grupo 2 y recibieron MMC al 0,02% durante 30seg sobre el lecho ablacionado. Un observador enmascarado midió el grosor corneal central (GCC) al mes y tres meses tras la cirugía. Comparamos el cambio en el GCC postoperatorio entre los dos grupos. La media de edad era de 31,5 (DE 4,6) años y 31,6 (DE 8,7) años en los grupos 1 y 2 respectivamente (p = 0,9). En el grupo 1, la media del GCC era 444,0 (DE 41,3) μm al mes y 450,3 (DE 43,5) μm a los tres meses (p = 0,04). El GCC en el grupo 2 era 399,7 (DE 31,2) μm al mes y 407,9 (DE 32,6) μm tres meses tras la cirugía (p = 0,006). La diferencia entre los incrementos de GCC entre los dos grupos no fue estadísticamente significativa (p = 0,6). Una única aplicación intraoperatoria de MMC al 0,02% durante 30 segundos no parece causar un cambio sustancial en el incremento del grosor corneal postoperatorio observado tras LASEK." @default.
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• W2006137389 date "2011-07-01" @default.
• W2006137389 modified "2023-10-13" @default.
• W2006137389 title "Effect of mitomycin C on corneal regrowth after laser-assisted sub-epithelial keratectomy (LASEK)" @default.
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• W2006137389 doi "https://doi.org/10.1016/j.oftale.2011.02.003" @default.
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