FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006141036> ?p ?o ?g. }

• W2006141036 endingPage "2492" @default.
• W2006141036 startingPage "2485" @default.
• W2006141036 abstract "Krox-20, a zinc finger transcription factor with similarity to Sp1, is likely to play an important role in the development of the vertebrate central nervous system. A knowledge of its molecular properties will help to understand its physiological functions. We have therefore performed a structure-function analysis of the protein to identify the regions involved in DNA-binding and transcriptional activation. Our data suggest that only the zinc fingers are required for high affinity, specific DNA-binding. Transcriptional activation was not affected by deletion of the C-terminal tail of the protein. In contrast, deletion of the N-terminal half, upstream of the zinc fingers, completely abolished transactivation without affecting DNA-binding or nuclear localization. Two transcriptional activation domains were identified in this region. They cooperate to establish full activity. They are rich in negatively-charged amino acids and are therefore may constitute acidic activation domains. Comparative analysis of the amino acid sequences of several zinc finger proteins belonging to the Krox-20 subfamily indicates that they contain acidic regions at similar locations within their N-terminal region, suggesting that the functional organization of these proteins has been conserved during evolution." @default.
• W2006141036 created "2016-06-24" @default.
• W2006141036 creator A5054477830 @default.
• W2006141036 creator A5069225949 @default.
• W2006141036 date "1992-01-01" @default.
• W2006141036 modified "2023-10-14" @default.
• W2006141036 title "Mapping functional regions of the segment-specific transcription factor Krox-20" @default.
• W2006141036 cites W119076594 @default.
• W2006141036 cites W1531234455 @default.
• W2006141036 cites W1868814633 @default.
• W2006141036 cites W1900996360 @default.
• W2006141036 cites W1965267927 @default.
• W2006141036 cites W1965609818 @default.
• W2006141036 cites W1975993749 @default.
• W2006141036 cites W1984751884 @default.
• W2006141036 cites W1984767179 @default.
• W2006141036 cites W1995733973 @default.
• W2006141036 cites W2004563262 @default.
• W2006141036 cites W2007675804 @default.
• W2006141036 cites W2013345205 @default.
• W2006141036 cites W2013446898 @default.
• W2006141036 cites W2014569682 @default.
• W2006141036 cites W2018289835 @default.
• W2006141036 cites W2025723633 @default.
• W2006141036 cites W2027305883 @default.
• W2006141036 cites W2031595029 @default.
• W2006141036 cites W2033777731 @default.
• W2006141036 cites W2037653294 @default.
• W2006141036 cites W2041101605 @default.
• W2006141036 cites W2041869959 @default.
• W2006141036 cites W2045284924 @default.
• W2006141036 cites W2045467759 @default.
• W2006141036 cites W2052537645 @default.
• W2006141036 cites W2052957716 @default.
• W2006141036 cites W2062579188 @default.
• W2006141036 cites W2068075345 @default.
• W2006141036 cites W2068577315 @default.
• W2006141036 cites W2071482027 @default.
• W2006141036 cites W2072325944 @default.
• W2006141036 cites W2077679480 @default.
• W2006141036 cites W2081748379 @default.
• W2006141036 cites W2083032333 @default.
• W2006141036 cites W2085206941 @default.
• W2006141036 cites W2088622701 @default.
• W2006141036 cites W2089126365 @default.
• W2006141036 cites W2091160336 @default.
• W2006141036 cites W2091423718 @default.
• W2006141036 cites W2091626902 @default.
• W2006141036 cites W2098026512 @default.
• W2006141036 cites W2099726434 @default.
• W2006141036 cites W2101108802 @default.
• W2006141036 cites W2109664605 @default.
• W2006141036 cites W2114339259 @default.
• W2006141036 cites W2132291850 @default.
• W2006141036 cites W2144206181 @default.
• W2006141036 cites W2147146361 @default.
• W2006141036 cites W2148069086 @default.
• W2006141036 cites W2155968662 @default.
• W2006141036 cites W2167921759 @default.
• W2006141036 cites W2429721485 @default.
• W2006141036 cites W2460820210 @default.
• W2006141036 doi "https://doi.org/10.1093/nar/20.10.2485" @default.
• W2006141036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/312382" @default.
• W2006141036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1598206" @default.
• W2006141036 hasPublicationYear "1992" @default.
• W2006141036 type Work @default.
• W2006141036 sameAs 2006141036 @default.
• W2006141036 citedByCount "45" @default.
• W2006141036 countsByYear W20061410362015 @default.
• W2006141036 countsByYear W20061410362017 @default.
• W2006141036 crossrefType "journal-article" @default.
• W2006141036 hasAuthorship W2006141036A5054477830 @default.
• W2006141036 hasAuthorship W2006141036A5069225949 @default.
• W2006141036 hasBestOaLocation W20061410361 @default.
• W2006141036 hasConcept C101762097 @default.
• W2006141036 hasConcept C104317684 @default.
• W2006141036 hasConcept C1292079 @default.
• W2006141036 hasConcept C138885662 @default.
• W2006141036 hasConcept C150194340 @default.
• W2006141036 hasConcept C167625842 @default.
• W2006141036 hasConcept C179926584 @default.
• W2006141036 hasConcept C199216141 @default.
• W2006141036 hasConcept C24284526 @default.
• W2006141036 hasConcept C2777124376 @default.
• W2006141036 hasConcept C2781435330 @default.
• W2006141036 hasConcept C3662595 @default.
• W2006141036 hasConcept C41895202 @default.
• W2006141036 hasConcept C50929876 @default.
• W2006141036 hasConcept C5432534 @default.
• W2006141036 hasConcept C54355233 @default.
• W2006141036 hasConcept C552990157 @default.
• W2006141036 hasConcept C57467964 @default.
• W2006141036 hasConcept C86339819 @default.
• W2006141036 hasConcept C86803240 @default.
• W2006141036 hasConcept C94966510 @default.
• W2006141036 hasConcept C95444343 @default.
• W2006141036 hasConceptScore W2006141036C101762097 @default.
• W2006141036 hasConceptScore W2006141036C104317684 @default.

• next