Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006145169> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2006145169 endingPage "146" @default.
- W2006145169 startingPage "143" @default.
- W2006145169 abstract "Metoclopramide (MCP) is a dopamine receptor antagonist and serotonin receptor agonist widely used as an antiemetic and gastric prokinetic drug. In addition MCP is a reversible inhibitor of cholinesterases from human central nervous system and blood. Metoclopramide may have a cholinesterase protective effect against inhibition by organophosphates. The purpose of the study was to quantify in vitro, by means of the ic50 shift, the extent of MCP conferred protection, using mipafox (MPFX) as an inhibitor. Mipafox is a neuropathic organophosphate. Cholinesterase activities (with acetylthiocholine [ChE-A] and butyrylthiocholine [ChE-B] as substrates) in human plasma were measured photometrically in the presence of different MPFX concentrations and the ic50 was calculated. Determinations were repeated in the presence of increasing MCP concentrations. It appears that the shift induced by the presence of MCP increases with the MCP concentration in a linear manner. In the presence of a clinically easily achievable plasma concentration of 1 µM MCP, the ic50 of MPFX for cholinesterase ‘shifts’ by a factor of ca. 3–6. The protective effect of MCP on cholinesterase could be of practical relevance in the treatment of organophosphate poisoning. We conclude that in vivo testing of MCP as an organophosphate protective agent is warranted. Copyright © 2004 John Wiley & Sons, Ltd." @default.
- W2006145169 created "2016-06-24" @default.
- W2006145169 creator A5003186088 @default.
- W2006145169 creator A5009520252 @default.
- W2006145169 creator A5028489349 @default.
- W2006145169 creator A5052555552 @default.
- W2006145169 creator A5057664335 @default.
- W2006145169 date "2004-03-01" @default.
- W2006145169 modified "2023-10-14" @default.
- W2006145169 title "In vitro protection of plasma cholinesterases by metoclopramide from inhibition by mipafox" @default.
- W2006145169 cites W1593576408 @default.
- W2006145169 cites W1599084717 @default.
- W2006145169 cites W1973198019 @default.
- W2006145169 cites W1973717475 @default.
- W2006145169 cites W1989363535 @default.
- W2006145169 cites W2010121395 @default.
- W2006145169 cites W2011692540 @default.
- W2006145169 cites W2025592718 @default.
- W2006145169 cites W2053836087 @default.
- W2006145169 cites W2073038133 @default.
- W2006145169 cites W2079607919 @default.
- W2006145169 cites W2122027418 @default.
- W2006145169 cites W2127954828 @default.
- W2006145169 doi "https://doi.org/10.1002/jat.964" @default.
- W2006145169 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15052610" @default.
- W2006145169 hasPublicationYear "2004" @default.
- W2006145169 type Work @default.
- W2006145169 sameAs 2006145169 @default.
- W2006145169 citedByCount "7" @default.
- W2006145169 countsByYear W20061451692014 @default.
- W2006145169 countsByYear W20061451692017 @default.
- W2006145169 crossrefType "journal-article" @default.
- W2006145169 hasAuthorship W2006145169A5003186088 @default.
- W2006145169 hasAuthorship W2006145169A5009520252 @default.
- W2006145169 hasAuthorship W2006145169A5028489349 @default.
- W2006145169 hasAuthorship W2006145169A5052555552 @default.
- W2006145169 hasAuthorship W2006145169A5057664335 @default.
- W2006145169 hasConcept C126322002 @default.
- W2006145169 hasConcept C150903083 @default.
- W2006145169 hasConcept C161176658 @default.
- W2006145169 hasConcept C181199279 @default.
- W2006145169 hasConcept C185592680 @default.
- W2006145169 hasConcept C207001950 @default.
- W2006145169 hasConcept C2776588719 @default.
- W2006145169 hasConcept C2778479196 @default.
- W2006145169 hasConcept C2778816929 @default.
- W2006145169 hasConcept C2779059548 @default.
- W2006145169 hasConcept C2779101902 @default.
- W2006145169 hasConcept C2780852908 @default.
- W2006145169 hasConcept C31896038 @default.
- W2006145169 hasConcept C55493867 @default.
- W2006145169 hasConcept C6557445 @default.
- W2006145169 hasConcept C71924100 @default.
- W2006145169 hasConcept C86803240 @default.
- W2006145169 hasConcept C98274493 @default.
- W2006145169 hasConceptScore W2006145169C126322002 @default.
- W2006145169 hasConceptScore W2006145169C150903083 @default.
- W2006145169 hasConceptScore W2006145169C161176658 @default.
- W2006145169 hasConceptScore W2006145169C181199279 @default.
- W2006145169 hasConceptScore W2006145169C185592680 @default.
- W2006145169 hasConceptScore W2006145169C207001950 @default.
- W2006145169 hasConceptScore W2006145169C2776588719 @default.
- W2006145169 hasConceptScore W2006145169C2778479196 @default.
- W2006145169 hasConceptScore W2006145169C2778816929 @default.
- W2006145169 hasConceptScore W2006145169C2779059548 @default.
- W2006145169 hasConceptScore W2006145169C2779101902 @default.
- W2006145169 hasConceptScore W2006145169C2780852908 @default.
- W2006145169 hasConceptScore W2006145169C31896038 @default.
- W2006145169 hasConceptScore W2006145169C55493867 @default.
- W2006145169 hasConceptScore W2006145169C6557445 @default.
- W2006145169 hasConceptScore W2006145169C71924100 @default.
- W2006145169 hasConceptScore W2006145169C86803240 @default.
- W2006145169 hasConceptScore W2006145169C98274493 @default.
- W2006145169 hasIssue "2" @default.
- W2006145169 hasLocation W20061451691 @default.
- W2006145169 hasLocation W20061451692 @default.
- W2006145169 hasOpenAccess W2006145169 @default.
- W2006145169 hasPrimaryLocation W20061451691 @default.
- W2006145169 hasRelatedWork W2006145169 @default.
- W2006145169 hasRelatedWork W2019080923 @default.
- W2006145169 hasRelatedWork W2026191608 @default.
- W2006145169 hasRelatedWork W2069888404 @default.
- W2006145169 hasRelatedWork W2083547938 @default.
- W2006145169 hasRelatedWork W2090255620 @default.
- W2006145169 hasRelatedWork W2092702444 @default.
- W2006145169 hasRelatedWork W209334162 @default.
- W2006145169 hasRelatedWork W2792639679 @default.
- W2006145169 hasRelatedWork W3110658424 @default.
- W2006145169 hasVolume "24" @default.
- W2006145169 isParatext "false" @default.
- W2006145169 isRetracted "false" @default.
- W2006145169 magId "2006145169" @default.
- W2006145169 workType "article" @default.