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- W2006146856 endingPage "1151" @default.
- W2006146856 startingPage "1142" @default.
- W2006146856 abstract "Bone is one of the few tissues in the human body with high endogenous healing capacity. However, failure of the healing process presents a significant clinical challenge; it is a tremendous burden for the individual and has related health and economic consequences. To overcome such healing deficits, various concepts for a local drug delivery to bone have been developed during the last decades. However, in many cases these concepts do not meet the specific requirements of either surgeons who must use these strategies or individual patients who might benefit from them. We describe currently available methods for local drug delivery and their limitations in therapy. Various solutions for drug delivery to bone focusing on clinical applications and intra-operative constraints are discussed and drug delivery by implant coating is highlighted. Finally, a new set of design and performance requirements for intra-operatively customized implant coatings for controlled drug delivery is proposed. In the future, these requirements may improve approaches for local and intra-operative treatment of patients." @default.
- W2006146856 created "2016-06-24" @default.
- W2006146856 creator A5012012839 @default.
- W2006146856 creator A5031177398 @default.
- W2006146856 creator A5036935672 @default.
- W2006146856 creator A5069236094 @default.
- W2006146856 creator A5086246300 @default.
- W2006146856 date "2012-09-01" @default.
- W2006146856 modified "2023-10-11" @default.
- W2006146856 title "Intra-operatively customized implant coating strategies for local and controlled drug delivery to bone" @default.
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