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- W2006149477 abstract "In Reply. —Dr Phillips reminds us of Dr Zelen's suggestions for alternatives to a strictly randomized trial. However, if those patients who choose not to give consent are different from those who do give consent on characteristics related to prognosis, interpretation of trial results will be difficult. This is a limitation of this alternative design. Dr Heimlich cites the widespread use of malariotherapy, even 30 years after the introduction of antibiotics, the award of the Nobel Prize to Warner-Jauregg in 1927, and the many uncontrolled case series as proof of its efficacy. These are all of great historical interest, but in our article we show how these anecdotal and case series data fail to settle the issue of efficacy. Can one demonstrate the efficacy of a treatment without an RCT? Perhaps medicine and epidemiology will develop new methods. In the meantime, the RCT provides objective evaluation of a treatment—a clear" @default.
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- W2006149477 title "Malaria Therapy: The Value of the Randomized Controlled Trial-Reply" @default.
- W2006149477 doi "https://doi.org/10.1001/jama.1993.03500020045015" @default.
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