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- W2006150293 abstract "One of the major challenges in the field of biomaterials engineering is the replication of the non-linear elasticity observed in soft tissues. In the present study, non-linearly elastic biomaterials were successfully fabricated from a chemically cross-linked elastomeric poly(glycerol sebacate) (PGS) and thermoplastic poly(L-lactic acid) (PLLA) using the core/shell electrospinning technique. The spun fibrous materials, containing a PGS core and PLLA shell, demonstrated J-shaped stress-strain curves, and having ultimate tensile strength, rupture elongation, and stiffness constants respectively comparable to muscle tissue properties. In vitro evaluations also showed that PGS/PLLA fibrous biomaterials possess excellent biocompatibility, capable of supporting human stem-cell-derived cardiomyocytes over several weeks in culture. Therefore, the core/shell electrospun elastomeric materials provide a new potential scaffold to support cells in the therapy of a wide range of soft tissues exposed to cyclic deformation, such as tendon, ligament, cardiac or smooth muscle and lung epithelium." @default.
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- W2006150293 date "2013-12-01" @default.
- W2006150293 modified "2023-10-18" @default.
- W2006150293 title "Mechanically tissue-like elastomeric polymers and their potential as a vehicle to deliver functional cardiomyocytes" @default.
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- W2006150293 doi "https://doi.org/10.1016/j.jmbbm.2013.06.005" @default.
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