FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006150892> ?p ?o ?g. }

• W2006150892 endingPage "125" @default.
• W2006150892 startingPage "121" @default.
• W2006150892 abstract "We have studied the rate and character with which testosterone (T) and 5 alpha-dihydrotestosterone (DHT) dissociate from the androgen receptor both within intact cultured genital skin fibroblasts of a subject with 5 alpha-reductase deficiency and after the androgen-receptor complexes have been extracted from the cells. Within the cells, the kinetics of the dissociative process for each hormone was first-order, but T dissociated four times faster than DHT. An Arrhenius plot of the variation of the dissociation rate constants with temperature for T was linear and yielded an activation energy of 28 kcal/mol. This value is identical with the one previously determined for activated DHT-receptor complexes. T-receptor complexes extracted from the cells dissociated with complex kinetics: at 37 degrees C the rate constants of the fast and slow components were 40 and 14 X 10(-3) min-1, respectively. In contrast, DHT-receptor complexes extracted from the cells dissociated with first-order kinetics and at a rate identical to that observed within cells, except after exposure to pyridoxal 5'-phosphate (5 mM) or concentration by Amicon (B-15) filtration, when their dissociation kinetics became complex. We interpret these data to mean that, within the cells, both T- and DHT-receptor complexes exist predominantly in the activated state whereas, when extracted from the cells, DHT-receptor complexes remain activated, unless perturbed, while T-receptor complexes become unstable spontaneously, probably by reverting to a preactivated state." @default.
• W2006150892 created "2016-06-24" @default.
• W2006150892 creator A5062074905 @default.
• W2006150892 creator A5062673255 @default.
• W2006150892 date "1983-02-01" @default.
• W2006150892 modified "2023-10-17" @default.
• W2006150892 title "The dissociation of testosterone- and 5α-dihydrotestosterone-receptor complexes formed within cultured human genital skin fibroblasts" @default.
• W2006150892 cites W1517737213 @default.
• W2006150892 cites W1544388792 @default.
• W2006150892 cites W156611903 @default.
• W2006150892 cites W1573981241 @default.
• W2006150892 cites W1672883562 @default.
• W2006150892 cites W1775749144 @default.
• W2006150892 cites W1981209718 @default.
• W2006150892 cites W1981296351 @default.
• W2006150892 cites W1981318616 @default.
• W2006150892 cites W1983649348 @default.
• W2006150892 cites W1990248614 @default.
• W2006150892 cites W1994556476 @default.
• W2006150892 cites W2004451483 @default.
• W2006150892 cites W2005123171 @default.
• W2006150892 cites W2009935531 @default.
• W2006150892 cites W2039114711 @default.
• W2006150892 cites W2090719793 @default.
• W2006150892 cites W2127657899 @default.
• W2006150892 cites W2142279517 @default.
• W2006150892 cites W2161349847 @default.
• W2006150892 cites W2325553783 @default.
• W2006150892 doi "https://doi.org/10.1016/0022-4731(83)90077-8" @default.
• W2006150892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6843115" @default.
• W2006150892 hasPublicationYear "1983" @default.
• W2006150892 type Work @default.
• W2006150892 sameAs 2006150892 @default.
• W2006150892 citedByCount "26" @default.
• W2006150892 countsByYear W20061508922012 @default.
• W2006150892 countsByYear W20061508922014 @default.
• W2006150892 countsByYear W20061508922016 @default.
• W2006150892 countsByYear W20061508922019 @default.
• W2006150892 crossrefType "journal-article" @default.
• W2006150892 hasAuthorship W2006150892A5062074905 @default.
• W2006150892 hasAuthorship W2006150892A5062673255 @default.
• W2006150892 hasConcept C102931765 @default.
• W2006150892 hasConcept C121332964 @default.
• W2006150892 hasConcept C121608353 @default.
• W2006150892 hasConcept C126322002 @default.
• W2006150892 hasConcept C134018914 @default.
• W2006150892 hasConcept C147789679 @default.
• W2006150892 hasConcept C148898269 @default.
• W2006150892 hasConcept C170493617 @default.
• W2006150892 hasConcept C185592680 @default.
• W2006150892 hasConcept C2777911890 @default.
• W2006150892 hasConcept C2779881493 @default.
• W2006150892 hasConcept C2780192828 @default.
• W2006150892 hasConcept C55493867 @default.
• W2006150892 hasConcept C61367390 @default.
• W2006150892 hasConcept C62520636 @default.
• W2006150892 hasConcept C71240020 @default.
• W2006150892 hasConcept C71315377 @default.
• W2006150892 hasConcept C71924100 @default.
• W2006150892 hasConcept C86803240 @default.
• W2006150892 hasConcept C8739425 @default.
• W2006150892 hasConcept C93391505 @default.
• W2006150892 hasConcept C95121573 @default.
• W2006150892 hasConceptScore W2006150892C102931765 @default.
• W2006150892 hasConceptScore W2006150892C121332964 @default.
• W2006150892 hasConceptScore W2006150892C121608353 @default.
• W2006150892 hasConceptScore W2006150892C126322002 @default.
• W2006150892 hasConceptScore W2006150892C134018914 @default.
• W2006150892 hasConceptScore W2006150892C147789679 @default.
• W2006150892 hasConceptScore W2006150892C148898269 @default.
• W2006150892 hasConceptScore W2006150892C170493617 @default.
• W2006150892 hasConceptScore W2006150892C185592680 @default.
• W2006150892 hasConceptScore W2006150892C2777911890 @default.
• W2006150892 hasConceptScore W2006150892C2779881493 @default.
• W2006150892 hasConceptScore W2006150892C2780192828 @default.
• W2006150892 hasConceptScore W2006150892C55493867 @default.
• W2006150892 hasConceptScore W2006150892C61367390 @default.
• W2006150892 hasConceptScore W2006150892C62520636 @default.
• W2006150892 hasConceptScore W2006150892C71240020 @default.
• W2006150892 hasConceptScore W2006150892C71315377 @default.
• W2006150892 hasConceptScore W2006150892C71924100 @default.
• W2006150892 hasConceptScore W2006150892C86803240 @default.
• W2006150892 hasConceptScore W2006150892C8739425 @default.
• W2006150892 hasConceptScore W2006150892C93391505 @default.
• W2006150892 hasConceptScore W2006150892C95121573 @default.
• W2006150892 hasIssue "2" @default.
• W2006150892 hasLocation W20061508921 @default.
• W2006150892 hasLocation W20061508922 @default.
• W2006150892 hasOpenAccess W2006150892 @default.
• W2006150892 hasPrimaryLocation W20061508921 @default.
• W2006150892 hasRelatedWork W2004261902 @default.
• W2006150892 hasRelatedWork W2011296913 @default.
• W2006150892 hasRelatedWork W2014676068 @default.
• W2006150892 hasRelatedWork W2053954521 @default.
• W2006150892 hasRelatedWork W2057609839 @default.
• W2006150892 hasRelatedWork W2059176014 @default.
• W2006150892 hasRelatedWork W2103250319 @default.
• W2006150892 hasRelatedWork W2136266902 @default.

• next