FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006155103> ?p ?o ?g. }

• W2006155103 endingPage "S171" @default.
• W2006155103 startingPage "S166" @default.
• W2006155103 abstract "Activation of the sarcolemmal sodium-hydrogen exchanger isoform-1 (NHE-1) in response to the intense intracellular acidosis that develops during ischemia has been identified as an important mechanism of myocardial cell injury. NHE-1 inhibition in the quiescent (nonfibrillating) heart ameliorates functional manifestation of ischemia and reperfusion injury. We investigated in isolated heart and intact rat models of ventricular fibrillation whether NHE-1 inhibition, by using the selective inhibitor cariporide, could ameliorate myocardial abnormalities that develop during ventricular fibrillation and limit resuscitability and survival. In the isolated rat heart, cariporide significantly reduced the magnitude of ischemic contracture during ventricular fibrillation and the accompanying increases in coronary vascular resistance. Hearts that had received cariporide during ventricular fibrillation had no diastolic dysfunction after resuscitation and recovered their systolic function earlier. In intact rats, cariporide given immediately before starting chest compression allowed generation of a coronary perfusion pressure and end-tidal Pco2 comparable with control rats but with significantly less depth of compression. Cariporide had an unprecedented effect in this rat model, prompting spontaneous defibrillation after approximately 8 mins of chest compression. After resuscitation, rats treated with cariporide had significantly less ventricular ectopic activity, better hemodynamic function, and higher survival rates (22 of 24 [94%] vs. 15 of 24 [63%] in control rats, p <.05). We conclude that NHE-1 inhibition may represent a novel and highly effective form of treatment for resuscitation from ventricular fibrillation." @default.
• W2006155103 created "2016-06-24" @default.
• W2006155103 creator A5010583145 @default.
• W2006155103 creator A5014186524 @default.
• W2006155103 creator A5040842847 @default.
• W2006155103 creator A5067107164 @default.
• W2006155103 date "2002-04-01" @default.
• W2006155103 modified "2023-10-10" @default.
• W2006155103 title "Myocardial protection during ventricular fibrillation by inhibition of the sodium-hydrogen exchanger isoform-1" @default.
• W2006155103 cites W13265411 @default.
• W2006155103 cites W1969843647 @default.
• W2006155103 cites W1971841026 @default.
• W2006155103 cites W1974852811 @default.
• W2006155103 cites W1980840854 @default.
• W2006155103 cites W1984209847 @default.
• W2006155103 cites W1986888244 @default.
• W2006155103 cites W2006816249 @default.
• W2006155103 cites W2007098223 @default.
• W2006155103 cites W2016909421 @default.
• W2006155103 cites W2019039631 @default.
• W2006155103 cites W2020908699 @default.
• W2006155103 cites W2023036252 @default.
• W2006155103 cites W2023332100 @default.
• W2006155103 cites W2027729256 @default.
• W2006155103 cites W2027779876 @default.
• W2006155103 cites W2028106043 @default.
• W2006155103 cites W2028984638 @default.
• W2006155103 cites W2033279834 @default.
• W2006155103 cites W2041774166 @default.
• W2006155103 cites W2042943866 @default.
• W2006155103 cites W2055582779 @default.
• W2006155103 cites W2056634083 @default.
• W2006155103 cites W2064532955 @default.
• W2006155103 cites W2065827934 @default.
• W2006155103 cites W2073141125 @default.
• W2006155103 cites W2079206063 @default.
• W2006155103 cites W2082615102 @default.
• W2006155103 cites W2085095498 @default.
• W2006155103 cites W2085944630 @default.
• W2006155103 cites W2089675043 @default.
• W2006155103 cites W2092819868 @default.
• W2006155103 cites W2106795011 @default.
• W2006155103 cites W2113440073 @default.
• W2006155103 cites W2120507882 @default.
• W2006155103 cites W2123443387 @default.
• W2006155103 cites W2126088174 @default.
• W2006155103 cites W2158452359 @default.
• W2006155103 cites W2161607654 @default.
• W2006155103 cites W2163749170 @default.
• W2006155103 cites W2163956812 @default.
• W2006155103 cites W2283818664 @default.
• W2006155103 cites W2416902400 @default.
• W2006155103 cites W328652316 @default.
• W2006155103 cites W4237107761 @default.
• W2006155103 cites W4248009949 @default.
• W2006155103 doi "https://doi.org/10.1097/00003246-200204001-00010" @default.
• W2006155103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11940795" @default.
• W2006155103 hasPublicationYear "2002" @default.
• W2006155103 type Work @default.
• W2006155103 sameAs 2006155103 @default.
• W2006155103 citedByCount "25" @default.
• W2006155103 countsByYear W20061551032012 @default.
• W2006155103 countsByYear W20061551032013 @default.
• W2006155103 countsByYear W20061551032014 @default.
• W2006155103 countsByYear W20061551032015 @default.
• W2006155103 countsByYear W20061551032016 @default.
• W2006155103 countsByYear W20061551032019 @default.
• W2006155103 crossrefType "journal-article" @default.
• W2006155103 hasAuthorship W2006155103A5010583145 @default.
• W2006155103 hasAuthorship W2006155103A5014186524 @default.
• W2006155103 hasAuthorship W2006155103A5040842847 @default.
• W2006155103 hasAuthorship W2006155103A5067107164 @default.
• W2006155103 hasConcept C114574056 @default.
• W2006155103 hasConcept C126322002 @default.
• W2006155103 hasConcept C164705383 @default.
• W2006155103 hasConcept C178790620 @default.
• W2006155103 hasConcept C185592680 @default.
• W2006155103 hasConcept C2777055891 @default.
• W2006155103 hasConcept C2777356233 @default.
• W2006155103 hasConcept C2777795826 @default.
• W2006155103 hasConcept C2777862461 @default.
• W2006155103 hasConcept C2778165595 @default.
• W2006155103 hasConcept C2779161974 @default.
• W2006155103 hasConcept C2781005686 @default.
• W2006155103 hasConcept C42219234 @default.
• W2006155103 hasConcept C500558357 @default.
• W2006155103 hasConcept C537181965 @default.
• W2006155103 hasConcept C541997718 @default.
• W2006155103 hasConcept C71924100 @default.
• W2006155103 hasConceptScore W2006155103C114574056 @default.
• W2006155103 hasConceptScore W2006155103C126322002 @default.
• W2006155103 hasConceptScore W2006155103C164705383 @default.
• W2006155103 hasConceptScore W2006155103C178790620 @default.
• W2006155103 hasConceptScore W2006155103C185592680 @default.
• W2006155103 hasConceptScore W2006155103C2777055891 @default.
• W2006155103 hasConceptScore W2006155103C2777356233 @default.
• W2006155103 hasConceptScore W2006155103C2777795826 @default.
• W2006155103 hasConceptScore W2006155103C2777862461 @default.

• next