Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006155478> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2006155478 endingPage "100" @default.
- W2006155478 startingPage "95" @default.
- W2006155478 abstract "The antipsychotic drug prochlorperazine was screened in vitro for possible antimicrobial property against 157 strains of bacteria, belonging to Gram positive and Gram negative genera. The minimum inhibitory concentration (MIC) of prochlorperazine was determined by agar dilution method, which ranged from 25 to 200 μg/ml with respect to most of the strains. Based on such findings, a further study was undertaken to determine whether the efficacy of this drug could be enhanced in the presence of an antihistaminic agent methdilazine, reported to have remarkable antimicrobial action. Four bacterial strains, sensitive to prochlorperazine as well as to three antibacterial chemotherapeutics, viz., methdilazine, fluphenazine and thioridazine were chosen. Disc diffusion tests with prochlorperazine and methdilazine revealed marked synergism between the combination, compared to their individual effects. The synergism was found to be statistically significant (p<0.01). To assess the degree of synergism, the checkerboard analysis was performed. The FIC index of this combination turned out to be 0.37, which confirmed synergism. Therefore, this synergistic drug combination might open a new therapeutic approach to combat drug-resistance in bacterial infections." @default.
- W2006155478 created "2016-06-24" @default.
- W2006155478 creator A5011032997 @default.
- W2006155478 creator A5047292776 @default.
- W2006155478 creator A5056585092 @default.
- W2006155478 creator A5064179966 @default.
- W2006155478 creator A5089127780 @default.
- W2006155478 date "2005-02-01" @default.
- W2006155478 modified "2023-10-06" @default.
- W2006155478 title "Antibacterial property of the antipsychotic agent prochlorperazine, and its synergism with methdilazine" @default.
- W2006155478 cites W1973397505 @default.
- W2006155478 cites W1982537960 @default.
- W2006155478 cites W1995190069 @default.
- W2006155478 cites W2030791006 @default.
- W2006155478 cites W2048199352 @default.
- W2006155478 cites W2063073547 @default.
- W2006155478 doi "https://doi.org/10.1016/j.micres.2004.10.002" @default.
- W2006155478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15782943" @default.
- W2006155478 hasPublicationYear "2005" @default.
- W2006155478 type Work @default.
- W2006155478 sameAs 2006155478 @default.
- W2006155478 citedByCount "39" @default.
- W2006155478 countsByYear W20061554782012 @default.
- W2006155478 countsByYear W20061554782013 @default.
- W2006155478 countsByYear W20061554782014 @default.
- W2006155478 countsByYear W20061554782015 @default.
- W2006155478 countsByYear W20061554782016 @default.
- W2006155478 countsByYear W20061554782017 @default.
- W2006155478 countsByYear W20061554782018 @default.
- W2006155478 countsByYear W20061554782019 @default.
- W2006155478 countsByYear W20061554782020 @default.
- W2006155478 countsByYear W20061554782021 @default.
- W2006155478 countsByYear W20061554782022 @default.
- W2006155478 countsByYear W20061554782023 @default.
- W2006155478 crossrefType "journal-article" @default.
- W2006155478 hasAuthorship W2006155478A5011032997 @default.
- W2006155478 hasAuthorship W2006155478A5047292776 @default.
- W2006155478 hasAuthorship W2006155478A5056585092 @default.
- W2006155478 hasAuthorship W2006155478A5064179966 @default.
- W2006155478 hasAuthorship W2006155478A5089127780 @default.
- W2006155478 hasConcept C118552586 @default.
- W2006155478 hasConcept C126322002 @default.
- W2006155478 hasConcept C169760540 @default.
- W2006155478 hasConcept C176947019 @default.
- W2006155478 hasConcept C2776412080 @default.
- W2006155478 hasConcept C2776978879 @default.
- W2006155478 hasConcept C2780035454 @default.
- W2006155478 hasConcept C2780493024 @default.
- W2006155478 hasConcept C2780494398 @default.
- W2006155478 hasConcept C2780580376 @default.
- W2006155478 hasConcept C2780948584 @default.
- W2006155478 hasConcept C2781324269 @default.
- W2006155478 hasConcept C4937899 @default.
- W2006155478 hasConcept C501593827 @default.
- W2006155478 hasConcept C513476851 @default.
- W2006155478 hasConcept C71924100 @default.
- W2006155478 hasConcept C86803240 @default.
- W2006155478 hasConcept C89423630 @default.
- W2006155478 hasConcept C98274493 @default.
- W2006155478 hasConceptScore W2006155478C118552586 @default.
- W2006155478 hasConceptScore W2006155478C126322002 @default.
- W2006155478 hasConceptScore W2006155478C169760540 @default.
- W2006155478 hasConceptScore W2006155478C176947019 @default.
- W2006155478 hasConceptScore W2006155478C2776412080 @default.
- W2006155478 hasConceptScore W2006155478C2776978879 @default.
- W2006155478 hasConceptScore W2006155478C2780035454 @default.
- W2006155478 hasConceptScore W2006155478C2780493024 @default.
- W2006155478 hasConceptScore W2006155478C2780494398 @default.
- W2006155478 hasConceptScore W2006155478C2780580376 @default.
- W2006155478 hasConceptScore W2006155478C2780948584 @default.
- W2006155478 hasConceptScore W2006155478C2781324269 @default.
- W2006155478 hasConceptScore W2006155478C4937899 @default.
- W2006155478 hasConceptScore W2006155478C501593827 @default.
- W2006155478 hasConceptScore W2006155478C513476851 @default.
- W2006155478 hasConceptScore W2006155478C71924100 @default.
- W2006155478 hasConceptScore W2006155478C86803240 @default.
- W2006155478 hasConceptScore W2006155478C89423630 @default.
- W2006155478 hasConceptScore W2006155478C98274493 @default.
- W2006155478 hasIssue "1" @default.
- W2006155478 hasLocation W20061554781 @default.
- W2006155478 hasLocation W20061554782 @default.
- W2006155478 hasOpenAccess W2006155478 @default.
- W2006155478 hasPrimaryLocation W20061554781 @default.
- W2006155478 hasRelatedWork W1570261267 @default.
- W2006155478 hasRelatedWork W1979973356 @default.
- W2006155478 hasRelatedWork W2065167888 @default.
- W2006155478 hasRelatedWork W2066829568 @default.
- W2006155478 hasRelatedWork W2068407850 @default.
- W2006155478 hasRelatedWork W2076387592 @default.
- W2006155478 hasRelatedWork W2403412381 @default.
- W2006155478 hasRelatedWork W2607252272 @default.
- W2006155478 hasRelatedWork W2753184995 @default.
- W2006155478 hasRelatedWork W3041641488 @default.
- W2006155478 hasVolume "160" @default.
- W2006155478 isParatext "false" @default.
- W2006155478 isRetracted "false" @default.
- W2006155478 magId "2006155478" @default.
- W2006155478 workType "article" @default.