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• W2006156983 abstract "In addition to its role as an inhibitory neurotransmitter, γ-aminobutyric acid (GABA) influences the cytodifferentiation of developing neurons both in culture and in vivo. Here, we report some of the targets of GABA action and the mechanism through which GABA acts. In primary cultures of cerebellar granule cells, GABA specifically stimulates an increase in the levels of mRNAs for α 1 and β 2 GABAA receptor subunits. The GABAA agonist 4, 5, 6, 7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP) mimics this effect, and the GABAA antagonist bicuculline prevents it. In addition, GABA and THIP trigger an increase in the number of GABA binding sites. This increase parallels that seen in vivo, where the total number of GABAA receptor sites increases during postnatal cerebellar development. It is interesting that the period of the greatest increase in the number of receptor sites coincides with the development of the granule cells. Taken together, our data suggest that GABA may play an important role during maturation of cerebellar granule cells by influencing the number and composition of its own receptors." @default.
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• W2006156983 date "1993-12-01" @default.
• W2006156983 modified "2023-09-27" @default.
• W2006156983 title "GABA Alters GABA_AReceptor mRNAs and Increases Ligand Binding" @default.
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• W2006156983 doi "https://doi.org/10.1111/j.1471-4159.1993.tb07481.x" @default.
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