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- W2006165909 abstract "Chronic pancreatitis predisposes to pancreatic cancer development and both diseases share a common etiology. A central role has been proposed for the digestive enzyme-secreting acinar cell that can undergo ductal metaplasia in the inflammatory environment of pancreatitis. This metaplastic change is now a recognised precursor of pancreatic cancer. Inflammatory molecules also foster tumour growth through autocrine and paracrine effects in the epithelium and the stroma. These insights have raised new opportunities such as the manipulation of inflammation as a preventive and/or therapeutic strategy for pancreatic cancer. Finally, we address the need for an in-depth study of the pancreatic acinar cells." @default.
- W2006165909 created "2016-06-24" @default.
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- W2006165909 date "2014-04-01" @default.
- W2006165909 modified "2023-09-30" @default.
- W2006165909 title "Chronic pancreatitis: A path to pancreatic cancer" @default.
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- W2006165909 doi "https://doi.org/10.1016/j.canlet.2013.08.015" @default.
- W2006165909 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23981573" @default.
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