FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006167464> ?p ?o ?g. }

• W2006167464 endingPage "140" @default.
• W2006167464 startingPage "125" @default.
• W2006167464 abstract "Here, we discuss three RNA-based therapeutic technologies exploiting various oligonucleotides that bind to RNA by base pairing in a sequence-specific manner yet have different mechanisms of action and effects. RNA interference and antisense oligonucleotides downregulate gene expression by inducing enzyme-dependent degradation of targeted mRNA. Steric-blocking oligonucleotides block the access of cellular machinery to pre-mRNA and mRNA without degrading the RNA. Through this mechanism, steric-blocking oligonucleotides can redirect alternative splicing, repair defective RNA, restore protein production or downregulate gene expression. Moreover, they can be extensively chemically modified to acquire more drug-like properties. The ability of RNA-blocking oligonucleotides to restore gene function makes them best suited for the treatment of genetic disorders. Positive results from clinical trials for the treatment of Duchenne muscular dystrophy show that this technology is close to achieving its clinical potential." @default.
• W2006167464 created "2016-06-24" @default.
• W2006167464 creator A5003873129 @default.
• W2006167464 creator A5029149817 @default.
• W2006167464 creator A5084668009 @default.
• W2006167464 date "2012-01-20" @default.
• W2006167464 modified "2023-10-09" @default.
• W2006167464 title "RNA therapeutics: beyond RNA interference and antisense oligonucleotides" @default.
• W2006167464 cites W1489906504 @default.
• W2006167464 cites W1533767429 @default.
• W2006167464 cites W1611419331 @default.
• W2006167464 cites W1647075334 @default.
• W2006167464 cites W1963871104 @default.
• W2006167464 cites W1964085020 @default.
• W2006167464 cites W1964196894 @default.
• W2006167464 cites W1965284203 @default.
• W2006167464 cites W1967023731 @default.
• W2006167464 cites W1968949098 @default.
• W2006167464 cites W1972376076 @default.
• W2006167464 cites W1972453061 @default.
• W2006167464 cites W1972637758 @default.
• W2006167464 cites W1972740819 @default.
• W2006167464 cites W1974303227 @default.
• W2006167464 cites W1975294548 @default.
• W2006167464 cites W1975680319 @default.
• W2006167464 cites W1976325953 @default.
• W2006167464 cites W1980477780 @default.
• W2006167464 cites W1984965097 @default.
• W2006167464 cites W1986402189 @default.
• W2006167464 cites W1990548509 @default.
• W2006167464 cites W1991714322 @default.
• W2006167464 cites W1991928630 @default.
• W2006167464 cites W1992972857 @default.
• W2006167464 cites W1996860050 @default.
• W2006167464 cites W1996948250 @default.
• W2006167464 cites W1997730532 @default.
• W2006167464 cites W2000725203 @default.
• W2006167464 cites W2001607290 @default.
• W2006167464 cites W2003066928 @default.
• W2006167464 cites W2004824383 @default.
• W2006167464 cites W2010506716 @default.
• W2006167464 cites W2010757394 @default.
• W2006167464 cites W2012284471 @default.
• W2006167464 cites W2015290966 @default.
• W2006167464 cites W2018862827 @default.
• W2006167464 cites W2022013776 @default.
• W2006167464 cites W2023985105 @default.
• W2006167464 cites W2025722577 @default.
• W2006167464 cites W2025816722 @default.
• W2006167464 cites W2027064784 @default.
• W2006167464 cites W2027954222 @default.
• W2006167464 cites W2030522563 @default.
• W2006167464 cites W2031204702 @default.
• W2006167464 cites W2035051422 @default.
• W2006167464 cites W2040743013 @default.
• W2006167464 cites W2044964290 @default.
• W2006167464 cites W2047689734 @default.
• W2006167464 cites W2048680477 @default.
• W2006167464 cites W2049670319 @default.
• W2006167464 cites W2052159624 @default.
• W2006167464 cites W2054281456 @default.
• W2006167464 cites W2054380003 @default.
• W2006167464 cites W2056546073 @default.
• W2006167464 cites W2056802142 @default.
• W2006167464 cites W2057734086 @default.
• W2006167464 cites W2058899285 @default.
• W2006167464 cites W2060842569 @default.
• W2006167464 cites W2062442451 @default.
• W2006167464 cites W2064634662 @default.
• W2006167464 cites W2065262709 @default.
• W2006167464 cites W2066950610 @default.
• W2006167464 cites W2069506489 @default.
• W2006167464 cites W2070936696 @default.
• W2006167464 cites W2072208716 @default.
• W2006167464 cites W2073115409 @default.
• W2006167464 cites W2076827123 @default.
• W2006167464 cites W2077577026 @default.
• W2006167464 cites W2079050210 @default.
• W2006167464 cites W2081280332 @default.
• W2006167464 cites W2083249633 @default.
• W2006167464 cites W2084091637 @default.
• W2006167464 cites W2090954313 @default.
• W2006167464 cites W2091439286 @default.
• W2006167464 cites W2103059478 @default.
• W2006167464 cites W2110154453 @default.
• W2006167464 cites W2112272980 @default.
• W2006167464 cites W2115222513 @default.
• W2006167464 cites W2115786681 @default.
• W2006167464 cites W2117224856 @default.
• W2006167464 cites W2118487660 @default.
• W2006167464 cites W2118586651 @default.
• W2006167464 cites W2121148907 @default.
• W2006167464 cites W2122933784 @default.
• W2006167464 cites W2130547944 @default.
• W2006167464 cites W2131032634 @default.
• W2006167464 cites W2136930242 @default.
• W2006167464 cites W2139093684 @default.
• W2006167464 cites W2150594659 @default.

• next