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• W2006173889 abstract "IN PREVIOUS STUDIES of the interaction of sedatives with thiopentone given intravenously, it was found that unstimulated trained dogs very often slept much longer than when thiopentone was administered alone. This response varied with the type of sedative given and was dose-related3 -~ This study was undertaken to determine whether a similar interaction occurs between representative sedatives commonly used and nonflammable halogenated inhalation anaesthetics, and to determine whether the response is primarily due to the dose of the sedative or to the concentration of the anaesthetic. METHODS Female albino rats of the CFE strain, of uniform age and size (weight approx. 200 gin), were used to carry out dose-response tests with several sedatives given intravenously, and with several inhalation anaesthetics administered with oxygen in a closed jar. Two problems had to be solved initially before the interactions could be studied. In order to reduce or eliminate as many gross physiological and pharmacological variables as possible, we had to determine the concentration of each anaesthetic which would produce a moderate depth of anaesthesia rapidly and the dose of sedative appropriate to cause light to moderate sedation within 10 minutes after intravenous injection. First it was necessary to determine the appropriate range of concentration for chloroform, trichlorethylene, halothane, methoxyflurane, enflurane and isoflurane between the ACs0 and the LC~o for this breed and size (age) of rat. This was accomplished by testing pairs of rats at various concentrations of each of the anaesthetics. Each pair of rats was placed in a jar of approximately 4 litres capacity filled with oxygen and a vapourised calculated dose of the liquid anaesthetic. After sealing, the jar was rotated manually 12 to 15 times per minute for 10 minutes. The speed with which unconsciousness and flaccidity supervened was observed and noted during this period. If the rats did not lose consciousness within three minutes, a higher concentration of the anaesthetic was tested with fresh rats until two appropriate doses ( concentrations ) were determined, at which" @default.
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• W2006173889 date "1973-07-01" @default.
• W2006173889 modified "2023-10-16" @default.
• W2006173889 title "Effect of premedication on duration of anaesthesia with halogenated vapours: Chloroform, trichlorethylene, halothane, methoxyflurane, enflurane (Ēthrane) and isoflurane (Forane)" @default.
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• W2006173889 doi "https://doi.org/10.1007/bf03026210" @default.
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