Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006194664> ?p ?o ?g. }
- W2006194664 endingPage "59" @default.
- W2006194664 startingPage "50" @default.
- W2006194664 abstract "The hedgehog (Hh) signaling pathways have a crucial role in cell proliferation and survival, and the de-regulation of these pathways can lead to tumorigenesis. Here we investigated the expression and function of these pathways in acute T lymphocytic leukemia cells (T-ALL). Profiling of Hh pathway members revealed common expression of key Hh signaling effectors in all T-ALL cells. We found that T-ALL cells were insensitive to specific Smoothened (SMO) inhibition following the use of low concentrations of the SMO antagonist cyclopamine. In contrast, treatment with the novel GLI antagonist GANT58 reduced expression of the target gene Patched 1 as well as GLI family zinc finger 1 (GLI1) and preferentially decreased the viability of T-ALL cells. We also found perifosine, a novel AKT inhibitor, down-regulated GLI1 protein by dephosphorylation of AKT and GSK3β dose-dependently and that pre-treatment with PD98059, a MEK/ERK pathway inhibitor, enhanced this down-regulation by 20%-30%. Then we questioned whether use of both GANT58 and AKT inhibitor together could confer a synergistic effect to decrease T-ALL cell viability. By applying the Chou-Talalay method, low concentration of GANT58 induced T-ALL cell death in a synergism fashion with perifosine or GSK690693 when used simultaneously. These findings indicate that the combined use of GANT58 and AKT inhibitor could help treat a broad range of malignant tumors in conjunction with existing cancer treatments." @default.
- W2006194664 created "2016-06-24" @default.
- W2006194664 creator A5004994683 @default.
- W2006194664 creator A5010812697 @default.
- W2006194664 creator A5017819585 @default.
- W2006194664 creator A5033532580 @default.
- W2006194664 creator A5046597133 @default.
- W2006194664 creator A5055151897 @default.
- W2006194664 creator A5063046834 @default.
- W2006194664 creator A5065594717 @default.
- W2006194664 creator A5074505725 @default.
- W2006194664 creator A5075726242 @default.
- W2006194664 creator A5079961094 @default.
- W2006194664 creator A5081619260 @default.
- W2006194664 date "2014-06-01" @default.
- W2006194664 modified "2023-09-25" @default.
- W2006194664 title "Inhibition of hedgehog signaling by GANT58 induces apoptosis and shows synergistic antitumor activity with AKT inhibitor in acute T cell leukemia cells" @default.
- W2006194664 cites W1966043852 @default.
- W2006194664 cites W1975104394 @default.
- W2006194664 cites W1976767488 @default.
- W2006194664 cites W1984379066 @default.
- W2006194664 cites W1997379399 @default.
- W2006194664 cites W1997889647 @default.
- W2006194664 cites W2002355858 @default.
- W2006194664 cites W2012335408 @default.
- W2006194664 cites W2014673454 @default.
- W2006194664 cites W2025663184 @default.
- W2006194664 cites W2029431452 @default.
- W2006194664 cites W2030199762 @default.
- W2006194664 cites W2031748054 @default.
- W2006194664 cites W2044348636 @default.
- W2006194664 cites W2049396238 @default.
- W2006194664 cites W2053820532 @default.
- W2006194664 cites W2054657634 @default.
- W2006194664 cites W2055296003 @default.
- W2006194664 cites W2055733507 @default.
- W2006194664 cites W2071644848 @default.
- W2006194664 cites W2077945404 @default.
- W2006194664 cites W2085324559 @default.
- W2006194664 cites W2086152184 @default.
- W2006194664 cites W2087896991 @default.
- W2006194664 cites W2089179512 @default.
- W2006194664 cites W2090176557 @default.
- W2006194664 cites W2090773805 @default.
- W2006194664 cites W2092536825 @default.
- W2006194664 cites W2099423360 @default.
- W2006194664 cites W2101476206 @default.
- W2006194664 cites W2105435030 @default.
- W2006194664 cites W2110321605 @default.
- W2006194664 cites W2111320234 @default.
- W2006194664 cites W2128775062 @default.
- W2006194664 cites W2130622321 @default.
- W2006194664 cites W2140154966 @default.
- W2006194664 cites W2144104511 @default.
- W2006194664 cites W2153653048 @default.
- W2006194664 cites W2161566367 @default.
- W2006194664 cites W2164195695 @default.
- W2006194664 cites W2164784911 @default.
- W2006194664 cites W4229861519 @default.
- W2006194664 doi "https://doi.org/10.1016/j.biochi.2013.12.019" @default.
- W2006194664 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24394624" @default.
- W2006194664 hasPublicationYear "2014" @default.
- W2006194664 type Work @default.
- W2006194664 sameAs 2006194664 @default.
- W2006194664 citedByCount "28" @default.
- W2006194664 countsByYear W20061946642014 @default.
- W2006194664 countsByYear W20061946642015 @default.
- W2006194664 countsByYear W20061946642016 @default.
- W2006194664 countsByYear W20061946642017 @default.
- W2006194664 countsByYear W20061946642018 @default.
- W2006194664 countsByYear W20061946642019 @default.
- W2006194664 countsByYear W20061946642020 @default.
- W2006194664 countsByYear W20061946642021 @default.
- W2006194664 countsByYear W20061946642022 @default.
- W2006194664 countsByYear W20061946642023 @default.
- W2006194664 crossrefType "journal-article" @default.
- W2006194664 hasAuthorship W2006194664A5004994683 @default.
- W2006194664 hasAuthorship W2006194664A5010812697 @default.
- W2006194664 hasAuthorship W2006194664A5017819585 @default.
- W2006194664 hasAuthorship W2006194664A5033532580 @default.
- W2006194664 hasAuthorship W2006194664A5046597133 @default.
- W2006194664 hasAuthorship W2006194664A5055151897 @default.
- W2006194664 hasAuthorship W2006194664A5063046834 @default.
- W2006194664 hasAuthorship W2006194664A5065594717 @default.
- W2006194664 hasAuthorship W2006194664A5074505725 @default.
- W2006194664 hasAuthorship W2006194664A5075726242 @default.
- W2006194664 hasAuthorship W2006194664A5079961094 @default.
- W2006194664 hasAuthorship W2006194664A5081619260 @default.
- W2006194664 hasConcept C145837895 @default.
- W2006194664 hasConcept C185592680 @default.
- W2006194664 hasConcept C190283241 @default.
- W2006194664 hasConcept C2777605378 @default.
- W2006194664 hasConcept C2777994357 @default.
- W2006194664 hasConcept C2778539099 @default.
- W2006194664 hasConcept C2779933373 @default.
- W2006194664 hasConcept C502942594 @default.
- W2006194664 hasConcept C53227056 @default.
- W2006194664 hasConcept C55493867 @default.