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- W2006195111 abstract "Abstract We investigated whether recipient dendritic cells (DCs), pretreated with nuclear factor‐κB oligodeoxyribonucleotide decoy (NF‐κB ODN decoy) and loaded with ultraviolet B‐irradiated donor apoptotic splenocytes (Apo‐SCs), were able to induce murine cardiac allograft tolerance. Heterotopic vascularized heart transplantation was performed from BALB/ c to C57BL/6 mice, and recipients (C57BL/6) were given one injection of recipient DCs pretreated with NF‐κB ODN decoy and loaded with donor (BALB/ c ) apoptotic SCs (decoy Apo‐SCs DCs) through the portal vein at 7 days, before heart transplantation in the absence of immunosuppression. The cardiac allograft survival time and the expressive levels of intragraft cytokine genes [interleukin (IL)‐2, IL‐10, and interferon‐γ] were evaluated. Our results indicated that injection of decoy Apo‐SCs DCs significantly prolonged vascularized heart allograft survival and led to skewing of intragraft cytokine expression towards T helper 2 (IL‐10). The mechanisms can be useful for therapy of allograft rejection with minimization of systemic immunosuppression." @default.
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- W2006195111 date "2004-04-01" @default.
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- W2006195111 title "Marked Prolongation of Murine Cardiac Allograft Survival Using Recipient Immature Dendritic Cells Loaded with Donor-Derived Apoptotic Cells" @default.
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- W2006195111 doi "https://doi.org/10.1111/j.1365-3083.2004.01427.x" @default.
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