FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006199669> ?p ?o ?g. }

• W2006199669 endingPage "14993" @default.
• W2006199669 startingPage "14983" @default.
• W2006199669 abstract "Myelin-specific proteins are either integral or peripheral membrane proteins that, in complex with lipids, constitute a multilayered proteolipid membrane system, the myelin sheath. The myelin sheath surrounds the axons of nerves and enables rapid conduction of axonal impulses. Myelin proteins interact intimately with the lipid bilayer and play crucial roles in the assembly, function, and stability of the myelin sheath. Although myelin proteins have been investigated for decades, their structural properties upon membrane surface binding are still largely unknown. In this study, we have used simplified model systems consisting of synthetic peptides and membrane mimics, such as detergent micelles and/or lipid vesicles, to probe the conformation of peptides using synchrotron radiation circular dichroism spectroscopy (SRCD). Additionally, oriented circular dichroism spectroscopy (OCD) was employed to examine the orientation of myelin peptides in macroscopically aligned lipid bilayers. Various representative peptides from the myelin basic protein (MBP), P0, myelin/oligodencrocyte glycoprotein, and connexin32 (cx32) were studied. A helical peptide from the central immunodominant epitope of MBP showed a highly tilted orientation with respect to the membrane surface, whereas the N-terminal cytoplasmic segment of cx32 folded into a helical structure that was only slightly tilted. The folding of full-length myelin basic protein was, furthermore, studied in a bicelle environment. Our results provide information on the conformation and membrane alignment of important membrane-binding peptides in a membrane-mimicking environment, giving novel insights into the mechanisms of membrane binding and stacking by myelin proteins." @default.
• W2006199669 created "2016-06-24" @default.
• W2006199669 creator A5011186052 @default.
• W2006199669 creator A5019494273 @default.
• W2006199669 creator A5037635585 @default.
• W2006199669 creator A5060799986 @default.
• W2006199669 creator A5086605859 @default.
• W2006199669 date "2013-11-22" @default.
• W2006199669 modified "2023-10-06" @default.
• W2006199669 title "Lipid Membrane Association of Myelin Proteins and Peptide Segments Studied by Oriented and Synchrotron Radiation Circular Dichroism Spectroscopy" @default.
• W2006199669 cites W1506459088 @default.
• W2006199669 cites W1508223815 @default.
• W2006199669 cites W1872790762 @default.
• W2006199669 cites W1967967251 @default.
• W2006199669 cites W1976731273 @default.
• W2006199669 cites W1978671493 @default.
• W2006199669 cites W1990550092 @default.
• W2006199669 cites W1997332996 @default.
• W2006199669 cites W2002963686 @default.
• W2006199669 cites W2004087319 @default.
• W2006199669 cites W2004698009 @default.
• W2006199669 cites W2008438037 @default.
• W2006199669 cites W2011915360 @default.
• W2006199669 cites W2013979901 @default.
• W2006199669 cites W2014550271 @default.
• W2006199669 cites W2015637511 @default.
• W2006199669 cites W2017882817 @default.
• W2006199669 cites W2025938842 @default.
• W2006199669 cites W2029737253 @default.
• W2006199669 cites W2031143043 @default.
• W2006199669 cites W2032977115 @default.
• W2006199669 cites W2033136849 @default.
• W2006199669 cites W2033405547 @default.
• W2006199669 cites W2039456470 @default.
• W2006199669 cites W2041797227 @default.
• W2006199669 cites W2042153675 @default.
• W2006199669 cites W2046279914 @default.
• W2006199669 cites W2048300387 @default.
• W2006199669 cites W2049681908 @default.
• W2006199669 cites W2052465711 @default.
• W2006199669 cites W2053518734 @default.
• W2006199669 cites W2053670655 @default.
• W2006199669 cites W2069592727 @default.
• W2006199669 cites W2071744579 @default.
• W2006199669 cites W2074706630 @default.
• W2006199669 cites W2074921617 @default.
• W2006199669 cites W2078231394 @default.
• W2006199669 cites W2079249370 @default.
• W2006199669 cites W2080202616 @default.
• W2006199669 cites W2080583464 @default.
• W2006199669 cites W2082207282 @default.
• W2006199669 cites W2082227039 @default.
• W2006199669 cites W2087260851 @default.
• W2006199669 cites W2089125684 @default.
• W2006199669 cites W2089749528 @default.
• W2006199669 cites W2094969375 @default.
• W2006199669 cites W2100637259 @default.
• W2006199669 cites W2101898606 @default.
• W2006199669 cites W2112509710 @default.
• W2006199669 cites W2114540884 @default.
• W2006199669 cites W2118014524 @default.
• W2006199669 cites W2121464522 @default.
• W2006199669 cites W2125110523 @default.
• W2006199669 cites W2129513939 @default.
• W2006199669 cites W2137325658 @default.
• W2006199669 cites W2138127628 @default.
• W2006199669 cites W2141606888 @default.
• W2006199669 cites W2147594885 @default.
• W2006199669 cites W2149327958 @default.
• W2006199669 cites W2150735552 @default.
• W2006199669 cites W2154080115 @default.
• W2006199669 cites W2168489873 @default.
• W2006199669 cites W2169700928 @default.
• W2006199669 cites W2335396054 @default.
• W2006199669 cites W2413568465 @default.
• W2006199669 cites W96323748 @default.
• W2006199669 doi "https://doi.org/10.1021/jp4098588" @default.
• W2006199669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24236572" @default.
• W2006199669 hasPublicationYear "2013" @default.
• W2006199669 type Work @default.
• W2006199669 sameAs 2006199669 @default.
• W2006199669 citedByCount "20" @default.
• W2006199669 countsByYear W20061996692015 @default.
• W2006199669 countsByYear W20061996692016 @default.
• W2006199669 countsByYear W20061996692017 @default.
• W2006199669 countsByYear W20061996692018 @default.
• W2006199669 countsByYear W20061996692019 @default.
• W2006199669 countsByYear W20061996692020 @default.
• W2006199669 countsByYear W20061996692021 @default.
• W2006199669 countsByYear W20061996692022 @default.
• W2006199669 countsByYear W20061996692023 @default.
• W2006199669 crossrefType "journal-article" @default.
• W2006199669 hasAuthorship W2006199669A5011186052 @default.
• W2006199669 hasAuthorship W2006199669A5019494273 @default.
• W2006199669 hasAuthorship W2006199669A5037635585 @default.
• W2006199669 hasAuthorship W2006199669A5060799986 @default.
• W2006199669 hasAuthorship W2006199669A5086605859 @default.
• W2006199669 hasBestOaLocation W20061996692 @default.

• next