Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006201220> ?p ?o ?g. }
- W2006201220 endingPage "67" @default.
- W2006201220 startingPage "61" @default.
- W2006201220 abstract "This study investigated the in vitro nail permeability of penetrants of varying lipophilicity—caffeine (CF, log P −0.07), methylparaben (MP, log P 1.96) and terbinafine (TBF, log P 3.3) and the effect of 2 novel penetration enhancers (PEs), thioglycolic acid (TA) and urea hydrogen peroxide (urea H2O2) on their permeation. Studies were conducted using full thickness human nail clippings and ChubTur® diffusion cells and penetrants were applied as saturated solutions. The rank order of steady-state penetrant flux through nails without PE application (MP > CF > TBF) suggested a greater sensitivity to penetrant molecular weight rather than log P. TA increased the flux of CF and MP ∼4- and ∼2-fold, respectively, whilst urea H2O2 proved ineffective at enhancing permeability. The sequential application of TA followed by urea H2O2 increased TBF and CF flux (∼19- and ∼4-fold, respectively) but reversing the application order of the PEs was only mildly effective at increasing just MP flux (∼2-fold). Both nail PEs are likely to function via disruption of keratin disulphide bonds and the associated formation of pores that provide more ‘open’ drug transport channels. Effects of the PEs were penetrant specific, but the use of a reducing agent (TA) followed by an oxidising agent (urea H2O2) dramatically improved human nail penetration." @default.
- W2006201220 created "2016-06-24" @default.
- W2006201220 creator A5024358940 @default.
- W2006201220 creator A5028608650 @default.
- W2006201220 creator A5041566087 @default.
- W2006201220 creator A5046419633 @default.
- W2006201220 creator A5068771233 @default.
- W2006201220 creator A5069886359 @default.
- W2006201220 creator A5078389670 @default.
- W2006201220 date "2009-03-31" @default.
- W2006201220 modified "2023-10-11" @default.
- W2006201220 title "Overcoming the nail barrier: A systematic investigation of ungual chemical penetration enhancement" @default.
- W2006201220 cites W1512686244 @default.
- W2006201220 cites W1963566978 @default.
- W2006201220 cites W1989201444 @default.
- W2006201220 cites W1989789102 @default.
- W2006201220 cites W1990853343 @default.
- W2006201220 cites W1991510878 @default.
- W2006201220 cites W1991670784 @default.
- W2006201220 cites W1992313340 @default.
- W2006201220 cites W1996540068 @default.
- W2006201220 cites W2005347256 @default.
- W2006201220 cites W2009852064 @default.
- W2006201220 cites W2016337768 @default.
- W2006201220 cites W2016691731 @default.
- W2006201220 cites W2019647609 @default.
- W2006201220 cites W2022057392 @default.
- W2006201220 cites W2023073262 @default.
- W2006201220 cites W2023574249 @default.
- W2006201220 cites W2024987974 @default.
- W2006201220 cites W2028862925 @default.
- W2006201220 cites W2031798741 @default.
- W2006201220 cites W2033702534 @default.
- W2006201220 cites W2036834622 @default.
- W2006201220 cites W2040098570 @default.
- W2006201220 cites W2040201659 @default.
- W2006201220 cites W2044961766 @default.
- W2006201220 cites W2047213593 @default.
- W2006201220 cites W2048648126 @default.
- W2006201220 cites W2053201770 @default.
- W2006201220 cites W2061242616 @default.
- W2006201220 cites W2073501188 @default.
- W2006201220 cites W2076340562 @default.
- W2006201220 cites W2077659386 @default.
- W2006201220 cites W2078281876 @default.
- W2006201220 cites W2080882412 @default.
- W2006201220 cites W2087453809 @default.
- W2006201220 cites W2089831809 @default.
- W2006201220 cites W2095841579 @default.
- W2006201220 cites W2100546663 @default.
- W2006201220 cites W2108016556 @default.
- W2006201220 cites W2109533181 @default.
- W2006201220 cites W2131152660 @default.
- W2006201220 cites W2132410889 @default.
- W2006201220 cites W2161518369 @default.
- W2006201220 cites W2183781285 @default.
- W2006201220 cites W2279230605 @default.
- W2006201220 cites W2484362470 @default.
- W2006201220 cites W3099595950 @default.
- W2006201220 cites W93532817 @default.
- W2006201220 cites W9842458 @default.
- W2006201220 doi "https://doi.org/10.1016/j.ijpharm.2008.11.009" @default.
- W2006201220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19071202" @default.
- W2006201220 hasPublicationYear "2009" @default.
- W2006201220 type Work @default.
- W2006201220 sameAs 2006201220 @default.
- W2006201220 citedByCount "65" @default.
- W2006201220 countsByYear W20062012202012 @default.
- W2006201220 countsByYear W20062012202013 @default.
- W2006201220 countsByYear W20062012202014 @default.
- W2006201220 countsByYear W20062012202015 @default.
- W2006201220 countsByYear W20062012202016 @default.
- W2006201220 countsByYear W20062012202017 @default.
- W2006201220 countsByYear W20062012202018 @default.
- W2006201220 countsByYear W20062012202019 @default.
- W2006201220 countsByYear W20062012202020 @default.
- W2006201220 countsByYear W20062012202021 @default.
- W2006201220 countsByYear W20062012202022 @default.
- W2006201220 countsByYear W20062012202023 @default.
- W2006201220 crossrefType "journal-article" @default.
- W2006201220 hasAuthorship W2006201220A5024358940 @default.
- W2006201220 hasAuthorship W2006201220A5028608650 @default.
- W2006201220 hasAuthorship W2006201220A5041566087 @default.
- W2006201220 hasAuthorship W2006201220A5046419633 @default.
- W2006201220 hasAuthorship W2006201220A5068771233 @default.
- W2006201220 hasAuthorship W2006201220A5069886359 @default.
- W2006201220 hasAuthorship W2006201220A5078389670 @default.
- W2006201220 hasBestOaLocation W20062012202 @default.
- W2006201220 hasConcept C12554922 @default.
- W2006201220 hasConcept C127413603 @default.
- W2006201220 hasConcept C13965031 @default.
- W2006201220 hasConcept C142724271 @default.
- W2006201220 hasConcept C155574463 @default.
- W2006201220 hasConcept C16005928 @default.
- W2006201220 hasConcept C178790620 @default.
- W2006201220 hasConcept C185592680 @default.
- W2006201220 hasConcept C2776745646 @default.
- W2006201220 hasConcept C2778370115 @default.