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• W2006203057 abstract "Signaling mechanisms for Blaberus discoidalis hypertrehalosemic hormone (Bld-HrTH)-dependent glycogen phosphorylase activation were investigated in vitro using fat body of the tropical cockroach, B. discoidalis. Brief treatment of fat bodies with Bld-HrTH in the absence of extracellular Ca2+ showed a significant activation of phosphorylase. Although extracellular Ca2+ was required for a full activation of phosphorylase by Bld-HrTH, stimulation in the absence of extracellular Ca2+ suggested that intracellular Ca2+ was also involved in Bld-HrTH signal transduction. Thapsigargin and thimerosal mobilize Ca2+ from intracellular stores by different mechanisms, and both chemicals stimulated phosphorylase activities as effectively as a maximum dose of Bld-HrTH. Bld-HrTH likely induces intracellular Ca2+ release followed by extracellular Ca2+ entry across the plasma membrane. Inositol-1,4,5-trisphosphate (InsP3) levels were greatly increased by Bld HrTH in a time- and dose-dependent manner, suggesting that InsP3 might be a Ca2+-mobilizing intracellular second messenger for Bld-HrTH." @default.
• W2006203057 created "2016-06-24" @default.
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• W2006203057 date "1996-02-05" @default.
• W2006203057 modified "2023-10-17" @default.
• W2006203057 title "Calcium-dependent action of hypertrehalosemic hormone on activation of glycogen phosphorylase in cockroach fat body" @default.
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• W2006203057 doi "https://doi.org/10.1016/0303-7207(95)03715-2" @default.
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