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- W2006207427 abstract "An irreversible inhibitor is often assessed as a potential drug on the basis of its specificity towards a target enzyme in vitro. This is inadequate because in vivo the enzyme may be re-synthesized and the inhibitor may react with other major body constituents, e.g. glutathione. Guidelines are given for selecting the class of inhibitor to be studied for use in a particular clinical area." @default.
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- W2006207427 title "Perspectives in the design of small molecule enzyme inhibitors as useful drugs" @default.
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- W2006207427 doi "https://doi.org/10.1016/0022-5193(78)90156-x" @default.
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