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- W2006215903 abstract "Abstract (2R) - and (2S)-[1-13C]-2-amino-2-methylmalonate, probes for the stereochemical course of the serine hydroxymethyltransferase reaction, have been synthesised from bis-lactim ethers derived from valine and alanine. Direct acylation of the anion with diethyl carbonate gave the N-ethoxycarbonyl derivative rather than the required ethyl ester. The 13C-labelled carboxyl group was therefore Introduced via treatment of the anion with [1-13C]-acetyl chloride, followed by haloform oxidation. The resulting carboxylate salt was then esterified with methyl iodide, and the bis-lactim ether ring system was cleaved under acidic conditions to give the amino acid esters. Saponification and then separation by cation exchange chromatography gave the title compounds." @default.
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- W2006215903 date "1991-01-01" @default.
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- W2006215903 title "Synthesis of (2R)- and (2S)- [1-13C]-2-amino-2-methylmalonic acid: Chiral substrates for serine hydroxymethyltransferase" @default.
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