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- W2006218483 abstract "Human adolescents consume alcohol largely to enhance social interactions. Adolescent, but not adult rats likewise exhibit ethanol-induced social facilitation under low-stress circumstances. Since the relationship between stress and ethanol sensitivity across ontogeny still has yet to be well explored, the present study sought to characterize possible age-associated differences in the influence of stressor exposure on ethanol-induced changes in social behavior in adolescent [postnatal days (P) 30–36] and adult (P65–71) male and female Sprague–Dawley rats. Animals were repeatedly restrained (90 min/day) for 5 days, followed by examination of ethanol-induced (0, 0.25, 0.5, 0.75, or 1.0 g/kg) alterations in social behaviors on the last day. Results revealed typical age-related differences in sensitivity to ethanol among controls, with adolescents being uniquely sensitive to low-dose ethanol stimulation of social investigation and play fighting, but less sensitive than adults to the social suppression emerging at higher doses. At both ages, stressor exposure decreased sensitivity to social inhibitory effects of ethanol, while augmenting expression of ethanol's social facilitatory effects. Ethanol also attenuated the stress-related suppression of social motivation at both ages. These results suggest that repeated stressor exposure diminishes age-related differences in the social consequences of ethanol, with stress enhancing ethanol-induced social facilitation across age." @default.
- W2006218483 created "2016-06-24" @default.
- W2006218483 creator A5000966943 @default.
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- W2006218483 date "2010-08-01" @default.
- W2006218483 modified "2023-10-03" @default.
- W2006218483 title "Repeated restraint stress alters sensitivity to the social consequences of ethanol in adolescent and adult rats" @default.
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- W2006218483 doi "https://doi.org/10.1016/j.pbb.2010.05.011" @default.
- W2006218483 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2911121" @default.
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