Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006222040> ?p ?o ?g. }
- W2006222040 endingPage "196" @default.
- W2006222040 startingPage "189" @default.
- W2006222040 abstract "Clopidogrel is a new thienopyridine derivative similar to ticlopidine, which inhibits adenosine diphosphate-induced platelet aggregation. The in vitro effects of clopidogrel on shear-induced platelet activation and coagulation were assessed after oral administration to rats, by subjecting non-anticoagulated blood to haemostatometry. Clopidogrel significantly inhibited shear-induced platelet activation and coagulation 2 h after administration at doses of 7.5 and 15 mg/kg. Both ticlopidine (200 mg/kg) and aspirin (200 mg/kg) inhibited shear-induced platelet activation, but not coagulation. The peak inhibition of plaetelet activation by clopidogrel occurred 2 h after oral administration, but significant inhibition persisted even after 24 h. These results suggest that clopidogrel could be a more potent antithrombotic agent than ticlopidine or aspirin, and also that ADP plays an important role in shear-induced platelet activation." @default.
- W2006222040 created "2016-06-24" @default.
- W2006222040 creator A5003589724 @default.
- W2006222040 creator A5027734328 @default.
- W2006222040 creator A5082568895 @default.
- W2006222040 creator A5087864910 @default.
- W2006222040 date "1999-01-01" @default.
- W2006222040 modified "2023-09-26" @default.
- W2006222040 title "Effects of Clopidogrel on Platelet Activation and Coagulation of Non-Anticoagulated Rat Blood under High Shear Stress" @default.
- W2006222040 cites W108310217 @default.
- W2006222040 cites W134833348 @default.
- W2006222040 cites W1568317078 @default.
- W2006222040 cites W1601949983 @default.
- W2006222040 cites W1926928802 @default.
- W2006222040 cites W1966221880 @default.
- W2006222040 cites W1978544877 @default.
- W2006222040 cites W1979698812 @default.
- W2006222040 cites W1992160009 @default.
- W2006222040 cites W1995309260 @default.
- W2006222040 cites W2006656509 @default.
- W2006222040 cites W2019920556 @default.
- W2006222040 cites W2021314204 @default.
- W2006222040 cites W2024342314 @default.
- W2006222040 cites W2039496408 @default.
- W2006222040 cites W2041361662 @default.
- W2006222040 cites W2053913287 @default.
- W2006222040 cites W2055435744 @default.
- W2006222040 cites W2056897856 @default.
- W2006222040 cites W2078333592 @default.
- W2006222040 cites W2085652917 @default.
- W2006222040 cites W2091244245 @default.
- W2006222040 cites W2101486946 @default.
- W2006222040 cites W2103679891 @default.
- W2006222040 cites W2149994976 @default.
- W2006222040 cites W2169030528 @default.
- W2006222040 cites W2259700787 @default.
- W2006222040 cites W2294445537 @default.
- W2006222040 cites W2313878230 @default.
- W2006222040 cites W2336611876 @default.
- W2006222040 cites W2408188083 @default.
- W2006222040 cites W2408373352 @default.
- W2006222040 cites W2408874283 @default.
- W2006222040 cites W2413466041 @default.
- W2006222040 cites W2414508679 @default.
- W2006222040 cites W2418491474 @default.
- W2006222040 cites W2419653627 @default.
- W2006222040 cites W2437361408 @default.
- W2006222040 cites W311320695 @default.
- W2006222040 cites W313570185 @default.
- W2006222040 cites W96204750 @default.
- W2006222040 doi "https://doi.org/10.1159/000022501" @default.
- W2006222040 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10702699" @default.
- W2006222040 hasPublicationYear "1999" @default.
- W2006222040 type Work @default.
- W2006222040 sameAs 2006222040 @default.
- W2006222040 citedByCount "6" @default.
- W2006222040 countsByYear W20062220402013 @default.
- W2006222040 crossrefType "journal-article" @default.
- W2006222040 hasAuthorship W2006222040A5003589724 @default.
- W2006222040 hasAuthorship W2006222040A5027734328 @default.
- W2006222040 hasAuthorship W2006222040A5082568895 @default.
- W2006222040 hasAuthorship W2006222040A5087864910 @default.
- W2006222040 hasConcept C126322002 @default.
- W2006222040 hasConcept C185592680 @default.
- W2006222040 hasConcept C2777015399 @default.
- W2006222040 hasConcept C2777399203 @default.
- W2006222040 hasConcept C2777628954 @default.
- W2006222040 hasConcept C2777849778 @default.
- W2006222040 hasConcept C2778382381 @default.
- W2006222040 hasConcept C2778905298 @default.
- W2006222040 hasConcept C2779837110 @default.
- W2006222040 hasConcept C2993802102 @default.
- W2006222040 hasConcept C3018697912 @default.
- W2006222040 hasConcept C71924100 @default.
- W2006222040 hasConcept C89560881 @default.
- W2006222040 hasConcept C98274493 @default.
- W2006222040 hasConceptScore W2006222040C126322002 @default.
- W2006222040 hasConceptScore W2006222040C185592680 @default.
- W2006222040 hasConceptScore W2006222040C2777015399 @default.
- W2006222040 hasConceptScore W2006222040C2777399203 @default.
- W2006222040 hasConceptScore W2006222040C2777628954 @default.
- W2006222040 hasConceptScore W2006222040C2777849778 @default.
- W2006222040 hasConceptScore W2006222040C2778382381 @default.
- W2006222040 hasConceptScore W2006222040C2778905298 @default.
- W2006222040 hasConceptScore W2006222040C2779837110 @default.
- W2006222040 hasConceptScore W2006222040C2993802102 @default.
- W2006222040 hasConceptScore W2006222040C3018697912 @default.
- W2006222040 hasConceptScore W2006222040C71924100 @default.
- W2006222040 hasConceptScore W2006222040C89560881 @default.
- W2006222040 hasConceptScore W2006222040C98274493 @default.
- W2006222040 hasIssue "4" @default.
- W2006222040 hasLocation W20062220401 @default.
- W2006222040 hasLocation W20062220402 @default.
- W2006222040 hasOpenAccess W2006222040 @default.
- W2006222040 hasPrimaryLocation W20062220401 @default.
- W2006222040 hasRelatedWork W131277697 @default.
- W2006222040 hasRelatedWork W1986164448 @default.
- W2006222040 hasRelatedWork W2006222040 @default.