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- W2006223856 abstract "The Landschütz ascites tumour was rendered immunogenic in A2G mice by prior in-vitro incubation with neuraminidase. Electrophoretic mobility studies of tumour cells and host spleen cells after neuraminidase treatment indicated that reduction of the total intercellular electrostatic charge between tumour and spleen cells below a critical level coincides with the detection of tumour antigens and subsequent immunity to inoculation with untreated tumour. It is concluded that the antigens on the Landschütz ascites tumour cells are masked from the host's immunologically competent cells by the sialic acid moiety of sialomucoproteins in the tumour cell wall. The results suggest that the free carboxyl groups of the sialic acid, by conferring a high negative charge to the cell periphery, inhibit the approach of lymphoid cells by Coulomb forces and thus inhibit antigen detection." @default.
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- W2006223856 date "1967-12-01" @default.
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- W2006223856 title "MASKING OF ANTIGENS ON THE LANDSCHÜTZ ASCITES TUMOUR" @default.
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- W2006223856 doi "https://doi.org/10.1016/s0140-6736(67)90918-x" @default.
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