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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006227978> ?p ?o ?g. }

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• W2006227978 abstract "Store-operated Ca(2+) entry (SOCE) through transient receptor potential (TRP) channels is important in the development of cardiac hypertrophy. Recently, stromal interaction molecule 1 (STIM1) was identified as a key regulator of SOCE. In this study, we examined whether STIM1 is involved in the development of cardiomyocyte hypertrophy. RT-PCR showed that cultured rat cardiomyocytes constitutively expressed STIM1. Endothelin-1 (ET-1) treatment for 48h enhanced TRPC1 expression, SOCE, and nuclear factor of activated T cells activation without upregulating STIM1. However, the knockdown of STIM1 suppressed these effects, thereby preventing a hypertrophic response. These results suggest that STIM1 plays an essential role in the development of cardiomyocyte hypertrophy." @default.
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• W2006227978 date "2009-11-01" @default.
• W2006227978 modified "2023-10-14" @default.
• W2006227978 title "Essential role of STIM1 in the development of cardiomyocyte hypertrophy" @default.
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• W2006227978 doi "https://doi.org/10.1016/j.bbrc.2009.08.117" @default.
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