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- W2006229968 abstract "We evaluated the pharmacokinetics of 5-fluorouracil (5-FU) combined with recombinant human interferon (IFN)-α2a in 10 previously untreated patients with advanced colorectal carcinoma. 5-FU was administered as a continuous i.v. infusion, 750 mg/m2/day for 5 days during week 1. One s.c. injection of IFN-α2a, 9 × 106 IU, was administered during week 2. Beginning with week 3, a continuous i.v. infusion of 5-FU 750 mg/m2/day for 5 days was administered in combination with IFN-22a, 9 × 1 0 6 IU s.c. three times per week. The combination of 5-FU and IFN-α2a was continued every other week until either 3 months after complete remission or tumor progression. No grade 4 toxicity was observed. Granulocytopenia (two patients), leukopenia (one patient), thrombocytopenia (one patient), stomatitis (two patients), fatigue (one patient) and hand-foot syndrome (one patient) were the major (grade 3) toxic reactions encountered. Overall, one complete and six partial responses were noted. The results of the paired t-test showed no statistically significant differences between the means of the two treatments, 5-FU and 5-FU plus IFN-α2a, with respect to the steady-state plasma concentration, area under the concentration-time curve, total body clearance, or steady-state volume of distribution of 5-FU, or the serum concentration of IFN. We conclude that 5-FU and IFN-α2a do not interact pharmacckinetically at the doses and schedules in the regimen studied." @default.
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- W2006229968 title "Pharmacokinetics of recombinant human interferon ??2a combined with 5-fluorouracil in patients with advanced colorectal carcinoma" @default.
- W2006229968 doi "https://doi.org/10.1097/00001813-199809000-00004" @default.
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