FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006232260> ?p ?o ?g. }

• W2006232260 endingPage "7" @default.
• W2006232260 startingPage "1" @default.
• W2006232260 abstract "Insect molting and metamorphosis are tightly controlled by ecdysteroids, which are important steroid hormones that are synthesized from dietary sterols in the prothoracic gland. One of the ecdysteroidogenic genes in the fruit fly Drosophila melanogaster is noppera-bo (nobo), also known as GSTe14, which encodes a member of the epsilon class of glutathione S-transferases. In D. melanogaster, nobo plays a crucial role in utilizing cholesterol via regulating its transport and/or metabolism in the prothoracic gland. However, it is still not known whether the orthologs of nobo from other insects are also involved in ecdysteroid biosynthesis via cholesterol transport and/or metabolism in the prothoracic gland. Here we report genetic evidence showing that the silkworm Bombyx mori ortholog of nobo (nobo-Bm; GSTe7) is essential for silkworm development. nobo-Bm is predominantly expressed in the prothoracic gland. To assess the functional importance of nobo-Bm, we generated a B. mori genetic mutant of nobo-Bm using TALEN-mediated genome editing. We show that loss of nobo-Bm function causes larval arrest and a glossy cuticle phenotype, which are rescued by the application of 20-hydroxyecdysone. Moreover, the prothoracic gland cells isolated from the nobo-Bm mutant exhibit an abnormal accumulation of 7-dehydrocholesterol, a cholesterol metabolite. These results suggest that the nobo family of glutathione S-transferases is essential for development and for the regulation of sterol utilization in the prothoracic gland in not only the Diptera but also the Lepidoptera. On the other hand, loss of nobo function mutants of D. melanogaster and B. mori abnormally accumulates different sterols, implying that the sterol utilization in the PG is somewhat different between these two insect species." @default.
• W2006232260 created "2016-06-24" @default.
• W2006232260 creator A5033292246 @default.
• W2006232260 creator A5050403187 @default.
• W2006232260 creator A5064036671 @default.
• W2006232260 creator A5075843623 @default.
• W2006232260 creator A5078870622 @default.
• W2006232260 creator A5080756133 @default.
• W2006232260 creator A5086070242 @default.
• W2006232260 creator A5090266698 @default.
• W2006232260 date "2015-06-01" @default.
• W2006232260 modified "2023-10-16" @default.
• W2006232260 title "The silkworm glutathione S-transferase gene noppera-bo is required for ecdysteroid biosynthesis and larval development" @default.
• W2006232260 cites W134964335 @default.
• W2006232260 cites W1496015783 @default.
• W2006232260 cites W1605668941 @default.
• W2006232260 cites W1927526647 @default.
• W2006232260 cites W1963535847 @default.
• W2006232260 cites W1971188096 @default.
• W2006232260 cites W1971689698 @default.
• W2006232260 cites W1985074478 @default.
• W2006232260 cites W1987341203 @default.
• W2006232260 cites W1998052111 @default.
• W2006232260 cites W2002803923 @default.
• W2006232260 cites W2004542444 @default.
• W2006232260 cites W2005366120 @default.
• W2006232260 cites W2005417359 @default.
• W2006232260 cites W2008548841 @default.
• W2006232260 cites W2012440175 @default.
• W2006232260 cites W2018317034 @default.
• W2006232260 cites W2019383872 @default.
• W2006232260 cites W2021327582 @default.
• W2006232260 cites W2025697998 @default.
• W2006232260 cites W2030589005 @default.
• W2006232260 cites W2039128629 @default.
• W2006232260 cites W2039174764 @default.
• W2006232260 cites W2051611053 @default.
• W2006232260 cites W2063689436 @default.
• W2006232260 cites W2071781675 @default.
• W2006232260 cites W2072578755 @default.
• W2006232260 cites W2076069532 @default.
• W2006232260 cites W2077271480 @default.
• W2006232260 cites W2084053040 @default.
• W2006232260 cites W2091827061 @default.
• W2006232260 cites W2092088565 @default.
• W2006232260 cites W2094384614 @default.
• W2006232260 cites W2107832177 @default.
• W2006232260 cites W2114755502 @default.
• W2006232260 cites W2114838239 @default.
• W2006232260 cites W2157228103 @default.
• W2006232260 cites W2161939072 @default.
• W2006232260 cites W2168245648 @default.
• W2006232260 cites W2171276689 @default.
• W2006232260 doi "https://doi.org/10.1016/j.ibmb.2015.04.001" @default.
• W2006232260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25881968" @default.
• W2006232260 hasPublicationYear "2015" @default.
• W2006232260 type Work @default.
• W2006232260 sameAs 2006232260 @default.
• W2006232260 citedByCount "55" @default.
• W2006232260 countsByYear W20062322602015 @default.
• W2006232260 countsByYear W20062322602016 @default.
• W2006232260 countsByYear W20062322602017 @default.
• W2006232260 countsByYear W20062322602018 @default.
• W2006232260 countsByYear W20062322602019 @default.
• W2006232260 countsByYear W20062322602020 @default.
• W2006232260 countsByYear W20062322602021 @default.
• W2006232260 countsByYear W20062322602022 @default.
• W2006232260 countsByYear W20062322602023 @default.
• W2006232260 crossrefType "journal-article" @default.
• W2006232260 hasAuthorship W2006232260A5033292246 @default.
• W2006232260 hasAuthorship W2006232260A5050403187 @default.
• W2006232260 hasAuthorship W2006232260A5064036671 @default.
• W2006232260 hasAuthorship W2006232260A5075843623 @default.
• W2006232260 hasAuthorship W2006232260A5078870622 @default.
• W2006232260 hasAuthorship W2006232260A5080756133 @default.
• W2006232260 hasAuthorship W2006232260A5086070242 @default.
• W2006232260 hasAuthorship W2006232260A5090266698 @default.
• W2006232260 hasBestOaLocation W20062322601 @default.
• W2006232260 hasConcept C104317684 @default.
• W2006232260 hasConcept C136397037 @default.
• W2006232260 hasConcept C143065580 @default.
• W2006232260 hasConcept C173758957 @default.
• W2006232260 hasConcept C2776905768 @default.
• W2006232260 hasConcept C2776998849 @default.
• W2006232260 hasConcept C2777180181 @default.
• W2006232260 hasConcept C2778332815 @default.
• W2006232260 hasConcept C2778487026 @default.
• W2006232260 hasConcept C2780104201 @default.
• W2006232260 hasConcept C47002013 @default.
• W2006232260 hasConcept C55493867 @default.
• W2006232260 hasConcept C59822182 @default.
• W2006232260 hasConcept C71315377 @default.
• W2006232260 hasConcept C86803240 @default.
• W2006232260 hasConcept C95444343 @default.
• W2006232260 hasConceptScore W2006232260C104317684 @default.
• W2006232260 hasConceptScore W2006232260C136397037 @default.
• W2006232260 hasConceptScore W2006232260C143065580 @default.
• W2006232260 hasConceptScore W2006232260C173758957 @default.

• next