Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006232498> ?p ?o ?g. }
- W2006232498 endingPage "688" @default.
- W2006232498 startingPage "682" @default.
- W2006232498 abstract "The aim of this study was to evaluate the possible role of prostacyclin (PGI2) in the pathogenesis of hypertension in spontaneously hypertensive rats (SHR).Measurement of mRNA and protein levels of PGH synthase (PGHS)-1, PGI2 synthase and the PGI2 receptor, in the thoracic aorta was performed in SHR aged 5, 10, 20, and 40 weeks old and in age-matched normotensive Wistar-Kyoto (WKY) rats with a competitive polymerase chain reaction method and immunoblotting. Aortic production of 6-keto-PGF1 alpha, the main metabolite of PGI2, was also measured.Compared with age-matched WKY rats, PGHS-1 mRNA and protein levels in the thoracic aorta of SHR increased with age, reaching three- and twofold higher than WKY rats at 40 weeks old, respectively. PGI2 synthase mRNA and protein levels in SHR were significantly higher than in WKY rats at 20 and 40 weeks old. In contrast, PGI2 receptor mRNA levels in SHR were consistently lower than in WKY rats at all ages.These results provide evidence that hypertension elicits alterations in levels of arachidonic acid metabolites, including PGH2 and PGI2. They also suggest that the decreased expression of PGI2 receptor mRNA in prehypertensive SHR could be one of the causes of hypertension in SHR." @default.
- W2006232498 created "2016-06-24" @default.
- W2006232498 creator A5013772972 @default.
- W2006232498 creator A5025363990 @default.
- W2006232498 creator A5040667304 @default.
- W2006232498 creator A5042203567 @default.
- W2006232498 creator A5048806914 @default.
- W2006232498 creator A5075895632 @default.
- W2006232498 creator A5081667035 @default.
- W2006232498 creator A5086287691 @default.
- W2006232498 date "1999-03-01" @default.
- W2006232498 modified "2023-10-13" @default.
- W2006232498 title "Altered gene expression of prostacyclin synthase and prostacyclin receptor in the thoracic aorta of spontaneously hypertensive rats" @default.
- W2006232498 cites W1572362848 @default.
- W2006232498 cites W1969388340 @default.
- W2006232498 cites W1972284975 @default.
- W2006232498 cites W1980581864 @default.
- W2006232498 cites W1989141136 @default.
- W2006232498 cites W2001195602 @default.
- W2006232498 cites W2003384285 @default.
- W2006232498 cites W2010498514 @default.
- W2006232498 cites W2013294996 @default.
- W2006232498 cites W2018987187 @default.
- W2006232498 cites W2021403302 @default.
- W2006232498 cites W2026628125 @default.
- W2006232498 cites W2029452319 @default.
- W2006232498 cites W2030057487 @default.
- W2006232498 cites W2031012349 @default.
- W2006232498 cites W2033421746 @default.
- W2006232498 cites W2041815458 @default.
- W2006232498 cites W2041945796 @default.
- W2006232498 cites W2047384198 @default.
- W2006232498 cites W2047924579 @default.
- W2006232498 cites W2058878434 @default.
- W2006232498 cites W2065249981 @default.
- W2006232498 cites W2066946422 @default.
- W2006232498 cites W2068479016 @default.
- W2006232498 cites W2071609839 @default.
- W2006232498 cites W2076042282 @default.
- W2006232498 cites W2082502803 @default.
- W2006232498 cites W2095715616 @default.
- W2006232498 cites W2101601744 @default.
- W2006232498 cites W2102802009 @default.
- W2006232498 cites W2104608140 @default.
- W2006232498 cites W2115207865 @default.
- W2006232498 cites W2127908196 @default.
- W2006232498 cites W2129254845 @default.
- W2006232498 cites W2137570167 @default.
- W2006232498 cites W2148016771 @default.
- W2006232498 cites W2148984051 @default.
- W2006232498 cites W2149897099 @default.
- W2006232498 cites W2159509362 @default.
- W2006232498 cites W2160418740 @default.
- W2006232498 cites W2169182236 @default.
- W2006232498 cites W2313098007 @default.
- W2006232498 cites W2399566180 @default.
- W2006232498 cites W2410656662 @default.
- W2006232498 cites W2420581706 @default.
- W2006232498 doi "https://doi.org/10.1016/s0008-6363(98)00239-9" @default.
- W2006232498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10435040" @default.
- W2006232498 hasPublicationYear "1999" @default.
- W2006232498 type Work @default.
- W2006232498 sameAs 2006232498 @default.
- W2006232498 citedByCount "67" @default.
- W2006232498 countsByYear W20062324982012 @default.
- W2006232498 countsByYear W20062324982013 @default.
- W2006232498 countsByYear W20062324982014 @default.
- W2006232498 countsByYear W20062324982015 @default.
- W2006232498 countsByYear W20062324982016 @default.
- W2006232498 countsByYear W20062324982017 @default.
- W2006232498 countsByYear W20062324982020 @default.
- W2006232498 countsByYear W20062324982022 @default.
- W2006232498 crossrefType "journal-article" @default.
- W2006232498 hasAuthorship W2006232498A5013772972 @default.
- W2006232498 hasAuthorship W2006232498A5025363990 @default.
- W2006232498 hasAuthorship W2006232498A5040667304 @default.
- W2006232498 hasAuthorship W2006232498A5042203567 @default.
- W2006232498 hasAuthorship W2006232498A5048806914 @default.
- W2006232498 hasAuthorship W2006232498A5075895632 @default.
- W2006232498 hasAuthorship W2006232498A5081667035 @default.
- W2006232498 hasAuthorship W2006232498A5086287691 @default.
- W2006232498 hasBestOaLocation W20062324981 @default.
- W2006232498 hasConcept C126322002 @default.
- W2006232498 hasConcept C134018914 @default.
- W2006232498 hasConcept C170493617 @default.
- W2006232498 hasConcept C181199279 @default.
- W2006232498 hasConcept C2776864027 @default.
- W2006232498 hasConcept C2778078955 @default.
- W2006232498 hasConcept C2778086073 @default.
- W2006232498 hasConcept C2779980429 @default.
- W2006232498 hasConcept C2780942790 @default.
- W2006232498 hasConcept C2781128415 @default.
- W2006232498 hasConcept C55493867 @default.
- W2006232498 hasConcept C71924100 @default.
- W2006232498 hasConcept C84393581 @default.
- W2006232498 hasConcept C86803240 @default.
- W2006232498 hasConceptScore W2006232498C126322002 @default.
- W2006232498 hasConceptScore W2006232498C134018914 @default.