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• W2006241458 abstract "The transcriptional properties of two cloned mouse tRNAAsp genes were examined in vitro. The tRNA(2Asp) gene displays a five fold greater transcriptional activity than the tRNA(1Asp) gene and a greater ability to form stable complexes with transcription factors. Transcription of a hybrid gene with swapped 5' flanking sequences and of 5' flanking region deletion mutants demonstrates that the differential transcription of the genes results from stimulatory sequences in the 5' flanking region of the tRNA(2Asp) gene. Distal sequences including those between positions -53 and -31 stimulate transcription but do not affect factor binding. Proximal sequences between positions -9 and -1 enhance factor binding. Thus, binding of transcription factors and later steps required for transcription can be modulated by separate and distinct 5' flanking sequence motifs in eukaryotic tRNA genes." @default.
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• W2006241458 date "1988-01-01" @default.
• W2006241458 modified "2023-09-26" @default.
• W2006241458 title "Transcriptional activity and factor binding are stimulated by separate and distinct sequences in the 5′ flanking region of a mouse tRNAAspgene" @default.
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• W2006241458 doi "https://doi.org/10.1093/nar/16.6.2509" @default.
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