FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2006242015> ?p ?o ?g. }

• W2006242015 endingPage "1200" @default.
• W2006242015 startingPage "1200" @default.
• W2006242015 abstract "Macular drusen are hallmarks of age-related maculopathy (ARM), but these focal extracellular lesions also appear with age in the peripheral retina. The present study was conducted to determine regional differences in morphology that contribute to the higher vulnerability of the macula to advanced disease.Drusen from the macula (n = 133) and periphery (n = 282) were isolated and concentrated from nine ARM-affected eyes. A semiquantitative light microscopic evaluation of 1-mum-thick sections included 12 parameters.Significant differences were found between the macula and periphery in ease of isolation, distribution of druse type, composition qualities, and substructures. On harvesting, macular drusen were friable, with liquefied or crystallized contents. Peripheral drusen were resilient and never crystallized. On examination, soft drusen appeared in the macula only, had homogeneous content without significant substructures, and had abundant basal laminar deposits (BlamD). Several substructures, previously postulated as signatures of druse biogenesis, were found primarily in hard drusen. Specific to hard drusen, which appeared everywhere, were central subregions and reduced RPE coverage. Macular hard drusen with a rich substructure profile differed from primarily homogeneous peripheral hard drusen. Compound drusen, found in the periphery only, exhibited a composition profile that was not intermediate between hard and soft.The data confirm regional differences in druse morphology, composition, and physical properties, most likely based on different formative mechanisms that may contribute to macular susceptibility for ARM progression. Two other reasons that only the macula is at high risk despite having relatively few drusen are the exclusive presence of soft drusen and the abundant BlamD in this region." @default.
• W2006242015 created "2016-06-24" @default.
• W2006242015 creator A5005513224 @default.
• W2006242015 creator A5010129221 @default.
• W2006242015 creator A5065561626 @default.
• W2006242015 creator A5082043337 @default.
• W2006242015 creator A5083537179 @default.
• W2006242015 creator A5088290696 @default.
• W2006242015 date "2008-03-01" @default.
• W2006242015 modified "2023-10-01" @default.
• W2006242015 title "Prevalence and Morphology of Druse Types in the Macula and Periphery of Eyes with Age-Related Maculopathy" @default.
• W2006242015 cites W159419684 @default.
• W2006242015 cites W180812339 @default.
• W2006242015 cites W180947891 @default.
• W2006242015 cites W1883306593 @default.
• W2006242015 cites W1964119221 @default.
• W2006242015 cites W1965997548 @default.
• W2006242015 cites W1979618033 @default.
• W2006242015 cites W1980954887 @default.
• W2006242015 cites W1982425456 @default.
• W2006242015 cites W1985731048 @default.
• W2006242015 cites W1987375871 @default.
• W2006242015 cites W1990558727 @default.
• W2006242015 cites W1992429621 @default.
• W2006242015 cites W1993828795 @default.
• W2006242015 cites W1994025305 @default.
• W2006242015 cites W1995006312 @default.
• W2006242015 cites W1996821302 @default.
• W2006242015 cites W1999383714 @default.
• W2006242015 cites W2000399151 @default.
• W2006242015 cites W2007104622 @default.
• W2006242015 cites W200886222 @default.
• W2006242015 cites W2009960960 @default.
• W2006242015 cites W2015642128 @default.
• W2006242015 cites W2016029218 @default.
• W2006242015 cites W2027707278 @default.
• W2006242015 cites W2036977833 @default.
• W2006242015 cites W2038364869 @default.
• W2006242015 cites W2046638324 @default.
• W2006242015 cites W2050580170 @default.
• W2006242015 cites W2063739407 @default.
• W2006242015 cites W2066326071 @default.
• W2006242015 cites W2069110097 @default.
• W2006242015 cites W2074342224 @default.
• W2006242015 cites W2077366389 @default.
• W2006242015 cites W2081972722 @default.
• W2006242015 cites W2084190964 @default.
• W2006242015 cites W2088551743 @default.
• W2006242015 cites W2092680451 @default.
• W2006242015 cites W2092816889 @default.
• W2006242015 cites W2099027894 @default.
• W2006242015 cites W2103495460 @default.
• W2006242015 cites W2127507482 @default.
• W2006242015 cites W2130142185 @default.
• W2006242015 cites W2136501493 @default.
• W2006242015 cites W2138437064 @default.
• W2006242015 cites W2156993091 @default.
• W2006242015 cites W2170201303 @default.
• W2006242015 cites W25541533 @default.
• W2006242015 cites W2583924966 @default.
• W2006242015 cites W42583700 @default.
• W2006242015 cites W5074286 @default.
• W2006242015 cites W82571716 @default.
• W2006242015 cites W1988212470 @default.
• W2006242015 cites W2605006999 @default.
• W2006242015 doi "https://doi.org/10.1167/iovs.07-1466" @default.
• W2006242015 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2279189" @default.
• W2006242015 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18326750" @default.
• W2006242015 hasPublicationYear "2008" @default.
• W2006242015 type Work @default.
• W2006242015 sameAs 2006242015 @default.
• W2006242015 citedByCount "145" @default.
• W2006242015 countsByYear W20062420152012 @default.
• W2006242015 countsByYear W20062420152013 @default.
• W2006242015 countsByYear W20062420152014 @default.
• W2006242015 countsByYear W20062420152015 @default.
• W2006242015 countsByYear W20062420152016 @default.
• W2006242015 countsByYear W20062420152017 @default.
• W2006242015 countsByYear W20062420152018 @default.
• W2006242015 countsByYear W20062420152019 @default.
• W2006242015 countsByYear W20062420152020 @default.
• W2006242015 countsByYear W20062420152021 @default.
• W2006242015 countsByYear W20062420152022 @default.
• W2006242015 countsByYear W20062420152023 @default.
• W2006242015 crossrefType "journal-article" @default.
• W2006242015 hasAuthorship W2006242015A5005513224 @default.
• W2006242015 hasAuthorship W2006242015A5010129221 @default.
• W2006242015 hasAuthorship W2006242015A5065561626 @default.
• W2006242015 hasAuthorship W2006242015A5082043337 @default.
• W2006242015 hasAuthorship W2006242015A5083537179 @default.
• W2006242015 hasAuthorship W2006242015A5088290696 @default.
• W2006242015 hasBestOaLocation W20062420151 @default.
• W2006242015 hasConcept C118487528 @default.
• W2006242015 hasConcept C134018914 @default.
• W2006242015 hasConcept C2776403814 @default.
• W2006242015 hasConcept C2778313320 @default.
• W2006242015 hasConcept C2779093074 @default.
• W2006242015 hasConcept C2780827179 @default.

• next